NCOA3 and ATAD2

Number of citations of the paper that reports this interaction (PubMedID 17998543)
47

Data Source:
HPRD (in vivo, in vitro)

		NCOA3	ATAD2
Description		nuclear receptor coactivator 3	ATPase family AAA domain containing 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity Disordered Domain Specific Binding	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Cellular Response To Hormone Stimulus Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Nucleosome Assembly Nucleosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4C16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	12 interacting genes: BAG4 BCAR3 CASP8 E2F1 E2F2 E2F3 E2F4 ESR1 H3-4 H4C14 MYC NCOA3
Entrez ID		8202	29028
HPRD ID		03570	10678
Ensembl ID		ENSG00000124151	ENSG00000156802
Uniprot IDs		Q59EE8 Q9Y6Q9	Q6PL18
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	3DAI 4QSP 4QSQ 4QSR 4QSS 4QST 4QSU 4QSV 4QSW 4QSX 4QUT 4QUU 4TT2 4TT4 4TT6 4TTE 4TU4 4TU6 4TYL 4TZ2 4TZ8 5A5N 5A5O 5A5P 5A5Q 5A5R 5A81 5A82 5A83 5EPB 5F36 5F3A 5LJ0 5QXI 5QXJ 5QXK 5QXL 5QXM 5QXN 5QXO 5QXP 5QXQ 5QXR 5QXS 5QXT 5QXU 5QXV 5QXW 5QXX 5QXY 5QXZ 5QY0 5R4E 5R4F 5R4V 5R4W 5R4X 5R4Y 5R4Z 6CPS 6EPJ 6EPR 6EPS 6EPT 6EPU 6EPV 6EPW 6EPX 6HDN 6HDO 6HI3 6HI4 6HI5 6HI6 6HI7 6HI8 6HIA 6HIB 6HIC 6HID 6HIE 6S55 6S56 6S57 6YB4 7M98 7PPX 7PX5 7Q6T 7Q6U 7Q6V 7Q6W 7QU7 7QUK 7QUM 7QWO 7QX1 7QXT 7QYK 7QYL 7QZM 7QZY 7QZZ 7R00 7R05 7R0Y 7Z9H 7Z9I 7Z9J 7Z9N 7Z9O 7Z9S 7Z9U 8H3H 8JUW 8JUY 8JUZ 8RU5 8SDO 8SDQ
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Signal Transduction Nucleoplasm Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Nucleus Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Protein Dimerization Activity Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex DNA-binding Transcription Activator Activity RNA Polymerase II Transcription Regulator Complex Chromatin DNA-binding Transcription Factor Activity Lens Fiber Cell Apoptotic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Fibroblast Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Developmental Process Chromatin Remodeling Apoptotic Signaling Pathway Response To Estradiol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Nucleoplasm Nucleobase-containing Compound Biosynthetic Process Sequence-specific DNA Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Protein-DNA Complex Assembly Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Transcription Coregulator Binding Regulation Of Myeloid Cell Differentiation Positive Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Epithelial Cell Apoptotic Process
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