PRG2 and PAPPA

Number of citations of the paper that reports this interaction (PubMedID 7685339)
0

Data Source:
HPRD (in vitro)

		PRG2	PAPPA
Description		proteoglycan 2, pro eosinophil major basic protein	pappalysin 1
Image
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Defense Response To Nematode Immune System Process Immune Response Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium	Proteolysis Cell Surface Receptor Signaling Pathway Female Pregnancy
Pathways		Neutrophil degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Sargramostim Chymopapain	Phenethyl Isothiocyanate
Diseases
GWAS		Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 18391950 20881960 28552196) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)
Interacting Genes		7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48	12 interacting genes: ATF7IP C3 CREBBP IGFBP4 KLHL20 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		5553	5069
HPRD ID		09283	01448
Ensembl ID		ENSG00000186652	ENSG00000182752
Uniprot IDs		P13727	B4DTA8 Q13219 Q7Z613
PDB IDs		1H8U 2BRS 4QXX 7Y5N 8HGG 9DKZ	7UFG 7Y5N 7Y5Q 8A7D 8A7E 8D8O 8HGG 8HGH
Enriched GO Terms of Interacting Partners?		Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Differentiation Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Regulation Of Sodium Ion Transport Regulation Of Apoptotic Signaling Pathway Regulation Of TRNA Methylation Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Cytokine Production Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Membrane Potential Response To Hormone Renin-angiotensin Regulation Of Aldosterone Production Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Growth Factor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Transport Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Regulation Of Steroid Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly	Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pericardium Development Trophoblast Cell Migration Intracellular Signaling Cassette Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Lens Fiber Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Homeostatic Process R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Chromatin Binding DNA-binding Transcription Factor Binding MiRNA Processing Endoderm Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction Ureteric Bud Development Negative Regulation Of Ossification Tau Protein Binding Epithelium Development Positive Regulation Of Multicellular Organismal Process Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development SMAD Binding Mesoderm Formation Protein Domain Specific Binding Transcription Coactivator Binding Phosphatase Binding Positive Regulation Of Cell Communication C5L2 Anaphylatoxin Chemotactic Receptor Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?