PRG2

Description		proteoglycan 2, pro eosinophil major basic protein
Image
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Defense Response To Nematode Immune System Process Immune Response Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium
Pathways		Neutrophil degranulation
Drugs		Sargramostim Chymopapain
Diseases
GWAS		Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)
Interacting Genes		7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48
Entrez ID		5553
HPRD ID		09283
Ensembl ID		ENSG00000186652
Uniprot IDs		P13727
PDB IDs		1H8U 2BRS 4QXX 7Y5N 8HGG 9DKZ
Enriched GO Terms of Interacting Partners?		Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Differentiation Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Regulation Of Sodium Ion Transport Regulation Of Apoptotic Signaling Pathway Regulation Of TRNA Methylation Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Cytokine Production Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Membrane Potential Response To Hormone Renin-angiotensin Regulation Of Aldosterone Production Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Growth Factor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Transport Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Regulation Of Steroid Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly
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