PRG2 and CSF2

Number of citations of the paper that reports this interaction (PMID 7727786)
15

Data Source:
HPRD (in vitro)

		PRG2	CSF2
Gene Name		proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	colony stimulating factor 2 (granulocyte-macrophage)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Transport Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Heparin Binding Carbohydrate Binding	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Defense Response To Nematode Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium	Embryonic Placenta Development Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Interleukin-23 Production Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Cytolysis Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)	Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		7 interactors: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48	7 interactors: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2
Entrez ID		5553	1437
HPRD ID		09283	00734
Ensembl ID			ENSG00000164400
Uniprot IDs		A6XMW0 P13727	P04141
PDB IDs		1H8U 2BRS	1CSG 2GMF 3CXE
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cell Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Peptidyl-tyrosine Phosphorylation Female Pregnancy Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Glucose Import Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Cell Death Positive Regulation Of Glucose Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Glucose Import Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Negative Regulation Of Signaling Negative Regulation Of Hydrolase Activity Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipase Activity Regulation Of Phosphorylation Reproductive Process Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Phospholipase Activity Regulation Of Oxidoreductase Activity Developmental Cell Growth Positive Regulation Of Peptidyl-serine Phosphorylation	Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Cytokine-mediated Signaling Pathway Response To Organic Substance Cellular Response To Cytokine Stimulus Interleukin-5-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Defense Response To Nematode Cellular Response To Organic Substance Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Mast Cell Apoptotic Process Somite Specification Positive Regulation Of Mast Cell Proliferation Response To Nematode Positive Regulation Of Melanocyte Differentiation Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation
Tagcloud ?			actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed
Tagcloud (Difference) ?			actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed
Tagcloud (Intersection) ?