CYFIP2 and WASF1

Number of citations of the paper that reports this interaction (PubMedID 16862120)
0

Data Source:
HPRD (in vitro, in vivo)

		CYFIP2	WASF1
Description		cytoplasmic FMR1 interacting protein 2	WASP family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Cell Adhesion Axon Guidance Cell Projection Assembly Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Cell-cell Adhesion Regulation Of Postsynapse Assembly	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31959851 32296059 34103634) Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		22 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A	38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10
Entrez ID		26999	8936
HPRD ID		07556	05434
Ensembl ID		ENSG00000055163	ENSG00000112290
Uniprot IDs		B7Z8N7 E7EVJ5 Q96F07	Q92558
PDB IDs			3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Actin Nucleation Lamellipodium Organization Lamellipodium Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Morphogenesis Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Cell Motility Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Postsynapse Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Actin Filament Organization Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Synapse Regulation Of Cell Projection Organization Translation Regulator Activity Positive Regulation Of Translation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Signaling Adaptor Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Signal Transduction Presynapse Positive Regulation Of Lamellipodium Organization Lamellipodium Assembly RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process MRNA 3'-UTR Binding	Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway
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