RAB2A and PMAIP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		RAB2A	PMAIP1
Name		RAB2A, member RAS oncogene family	phorbol-12-myristate-13-acetate-induced protein 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Glucose Starvation T Cell Homeostasis Positive Regulation Of Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation	Activation of NOXA and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
GWAS		Aspartate aminotransferase levels ( 33547301 ) Autoimmune thyroid disease ( 32581359 ) Estimated glomerular filtration rate ( 31152163 ) Low density lipoprotein cholesterol levels ( 32154731 ) Neutrophil count ( 32888494 ) Systemic sclerosis ( 31672989 ) Total cholesterol levels ( 29083408 )	Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 23669352 26426971 28892062 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Coronary artery disease ( 33020668 26343387 ) HDL cholesterol levels ( 32203549 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) Metabolic syndrome ( 20694148 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Regular attendance at a pub or social club ( 29970889 ) Restless legs syndrome ( 33239738 ) Schizophrenia x sex interaction ( 34099189 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Interacting Genes		29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7	13 interacting genes: BAX BCL2 BCL2A1 BCL2L1 GSK3B MCL1 PPBP RAB2A RNF7 STUB1 UBE2D1 UBE2D2 ZBTB16
Entrez ID		5862	5366
HPRD ID		01539	12002
Ensembl ID		ENSG00000104388	ENSG00000141682
Uniprot IDs		P61019	A0A0S2Z490 A0A0S2Z4V2 Q13794
PDB IDs		1Z0A	3MQP
GO Terms Enriched among Interactors		None	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand BH3 Domain Binding Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Channel Activity Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Apoptotic Mitochondrial Changes Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrial Outer Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Response To Endoplasmic Reticulum Stress Programmed Cell Death Involved In Cell Development Negative Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Anoikis Negative Regulation Of Apoptotic Process Mitochondrial Membrane Organization Negative Regulation Of Programmed Cell Death Protein Polyubiquitination Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Organelle Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Ubiquitination Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Autophagy Leukocyte Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Gamma Radiation