RAB2A and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RAB2A	MAPKAPK3
Description		RAB2A, member RAS oncogene family	MAPK activated protein kinase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation	p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs			2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Autoimmune thyroid disease ( 32581359) Estimated glomerular filtration rate ( 31152163) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Systemic sclerosis ( 31672989) Total cholesterol levels ( 29083408)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7	21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		5862	7867
HPRD ID		01539	03678
Ensembl ID		ENSG00000104388	ENSG00000114738
Uniprot IDs		P61019	Q16644
PDB IDs		1Z0A	3FHR 3FXW 3R1N 3SHE 7NRB
Enriched GO Terms of Interacting Partners?			Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome
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