CPAP and BCCIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPAP	BCCIP
Description		centrosome assembly and centriole elongation protein	BRCA2 and CDKN1A interacting protein
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GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Gamma-tubulin Small Complex Ciliary Basal Body Procentriole Replication Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Spindle Pole
	Molecular Function	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding	RNA Binding Protein Binding Tubulin Binding Kinase Regulator Activity
	Biological Process	Microtubule Nucleation Centriole Replication Smoothened Signaling Pathway Astral Microtubule Nucleation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Microtubule Polymerization Centrosome Duplication Cell Division Regulation Of Mitotic Spindle Organization Cilium Assembly Centriole Elongation Centriole Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Assembly Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization Non-motile Cilium Assembly Positive Regulation Of Spindle Assembly	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization DNA Repair DNA Damage Response Mitotic Spindle Organization Microtubule Anchoring Neuroendocrine Cell Differentiation Mitotic Spindle Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs
Diseases		Primary microcephaly (MCPH) Seckel syndrome
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH SHANK3 STAT5A STAT5B TUBG1 YWHAG YWHAZ	28 interacting genes: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDC42 CDKN1A CPAP CSNK2B FCF1 GSK3A GSK3B H2BC15 HMGB2 ITSN2 MRPS9 OGT PDGFB PTN PTPRM RAD51 RALY RPL23 RPL38 SRC TENT5A ZNF138 ZNF19
Entrez ID		55835	56647
HPRD ID		09876	16542
Ensembl ID		ENSG00000151849	ENSG00000107949
Uniprot IDs		A8K8P1 F6VUX8 Q9HC77	Q9P287
PDB IDs		5EIB 5ITZ 7Q1E 7Q1F 7Z0F 7Z0G	7KYQ 7KYS 8EQB 8EXE 8EXF
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Cell Killing Leukocyte Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Development Of Secondary Sexual Characteristics Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Lymphocyte Activation Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Production Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Gamma-delta T Cell Differentiation Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Luteinization Negative Regulation Of Erythrocyte Differentiation Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Hemopoiesis Positive Regulation Of Cell Killing Taurine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell Development Regulation Of Natural Killer Cell Differentiation Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Immune Effector Process Negative Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Developmental Process Myeloid Cell Apoptotic Process Positive Regulation Of B Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response	Nuclear Ubiquitin Ligase Complex Mitotic Recombination-dependent Replication Fork Processing Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Damage Checkpoint Cellular Response To Ionizing Radiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Glycogen (starch) Synthase Activity Protein-containing Complex Regulation Of Epithelial Cell Proliferation Regulation Of Cell-substrate Adhesion Negative Regulation Of Catabolic Process Regulation Of Proteolysis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Response To Glycoside Regulation Of Protein Modification Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Ionizing Radiation Regulation Of Protein Metabolic Process Response To Gamma Radiation Negative Regulation Of Proteolysis Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of TOR Signaling Cellular Response To Antibiotic Regulation Of Cell Migration Negative Regulation Of Catalytic Activity Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Regulation Of Intracellular Signal Transduction Cellular Response To Radiation Apoptotic Signaling Pathway Regulation Of Cell Motility
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