CENPJ and LAG3

Number of citations of the paper that reports this interaction (PMID 11592063)
2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CENPJ	LAG3
Gene Name		centromere protein J	lymphocyte-activation gene 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Centriole Cytosol Microtubule Gamma-tubulin Small Complex	External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding	Antigen Binding Transmembrane Signaling Receptor Activity MHC Class II Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Centriole Replication Regulation Of Centriole Replication Microtubule Polymerization Cell Division	Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATN1 CIC CREBBP EPB41 GFI1B LAG3 LYST RELA STAT5A STAT5B TUBG1 YWHAG YWHAZ	2 interactors: CEBPZ CENPJ
Entrez ID		55835	3902
HPRD ID		09876	01077
Ensembl ID		ENSG00000151849	ENSG00000089692
Uniprot IDs		A8K8P1 Q9HC77	P18627
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Cytokine Biosynthetic Process Development Of Secondary Male Sexual Characteristics Creatinine Metabolic Process Positive Regulation Of Innate Immune Response Isoleucine Metabolic Process Allantoin Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Peptide Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of B Cell Differentiation 2-oxoglutarate Metabolic Process Peyer's Patch Development Positive Regulation Of Cytokine Production Oxaloacetate Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Lymphocyte Activation Natural Killer Cell Differentiation Immune System Process Positive Regulation Of Activated T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Immune System Process	Regulation Of Centriole Replication Centriole Replication Microtubule Nucleation Centriole Assembly Microtubule Polymerization Centrosome Duplication Microtubule Polymerization Or Depolymerization Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Centrosome Cycle
Tagcloud ?		acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed	aspects burdens coincides exhibiting experimentally granulomas granulomatous helper immunodeficiency immunomodulatory killer latent lungs lymphocyte macaca macaques modulates mtb mulatta nonhuman persist presumably primate primates reactivation recapitulates rhesus simian tuberculosis
Tagcloud (Difference) ?		acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed	aspects burdens coincides exhibiting experimentally granulomas granulomatous helper immunodeficiency immunomodulatory killer latent lungs lymphocyte macaca macaques modulates mtb mulatta nonhuman persist presumably primate primates reactivation recapitulates rhesus simian tuberculosis
Tagcloud (Intersection) ?