CENPJ and LYST

Number of citations of the paper that reports this interaction (PMID 11984006)
18

Data Source:
BioGRID (two hybrid)

		CENPJ	LYST
Gene Name		centromere protein J	lysosomal trafficking regulator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Centriole Cytosol Microtubule Gamma-tubulin Small Complex	Cytosol Endomembrane System Microtubule Cytoskeleton Extrinsic Component Of Membrane
	Molecular Function	Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding	Protein Binding Phospholipid Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Centriole Replication Regulation Of Centriole Replication Microtubule Polymerization Cell Division	Neutrophil Mediated Immunity T Cell Mediated Immunity Phospholipid Metabolic Process Microtubule-based Process Lysosome Organization Blood Coagulation Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Response To Drug Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Phospholipid Homeostasis
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATN1 CIC CREBBP EPB41 GFI1B LAG3 LYST RELA STAT5A STAT5B TUBG1 YWHAG YWHAZ	24 interactors: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DGCR14 DNAJC14 EFS ESRRA HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521
Entrez ID		55835	1130
HPRD ID		09876	06060
Ensembl ID		ENSG00000151849	ENSG00000143669
Uniprot IDs		A8K8P1 Q9HC77	Q99698
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Cytokine Biosynthetic Process Development Of Secondary Male Sexual Characteristics Creatinine Metabolic Process Positive Regulation Of Innate Immune Response Isoleucine Metabolic Process Allantoin Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Peptide Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of B Cell Differentiation 2-oxoglutarate Metabolic Process Peyer's Patch Development Positive Regulation Of Cytokine Production Oxaloacetate Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Lymphocyte Activation Natural Killer Cell Differentiation Immune System Process Positive Regulation Of Activated T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Immune System Process	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Mitochondrion Organization Protein Targeting Alternative MRNA Splicing, Via Spliceosome Regulation Of Mitochondrion Organization Centriole Replication Membrane Organization Gene Expression Protein Transport Centriole Assembly Establishment Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Centrosome Duplication ERBB Signaling Pathway Positive Regulation Of Transport Substantia Nigra Development Regulation Of Intracellular Transport Intrinsic Apoptotic Signaling Pathway Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Neural Nucleus Development Intracellular Protein Transport Centrosome Cycle Protein Localization Positive Regulation Of Intracellular Transport Apoptotic Process Establishment Of Localization In Cell Developmental Process Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Programmed Cell Death Intracellular Transport Regulation Of Cellular Localization Cell Death Death Anatomical Structure Development Mitochondrial Translation System Development Midbrain Development Golgi Reassembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity RNA Splicing
Tagcloud ?		acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?