ARPC4 and ARPC2

Number of citations of the paper that reports this interaction (PMID 11162547)
1

Data Source:
HPRD (two hybrid)

		ARPC4	ARPC2
Gene Name		actin related protein 2/3 complex, subunit 4, 20kDa	actin related protein 2/3 complex, subunit 2, 34kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Cell Projection Extracellular Vesicular Exosome	Cytoplasm Endosome Golgi Apparatus Cytosol Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Leading Edge Neuron Projection Synapse Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Binding, Bridging Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Kinesin Binding AP-1 Adaptor Complex Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Axon Guidance Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Innate Immune Response Ephrin Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Axon Guidance Positive Regulation Of Lamellipodium Assembly Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L NELFCD PNMA5 RNF130	6 interactors: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS
Entrez ID		10093	10109
HPRD ID		10368	10367
Ensembl ID		ENSG00000241553	ENSG00000163466
Uniprot IDs		P59998	O15144 Q53R19
PDB IDs
Enriched GO Terms of Interacting Partners?		Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Organelle Organization Phagocytosis Fc Receptor Signaling Pathway Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Meiotic Chromosome Movement Towards Spindle Pole Immune Response-regulating Signaling Pathway Axonogenesis Axon Development Asymmetric Cell Division Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Component Organization Chemotaxis Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Meiotic Cytokinesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Innate Immune Response Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response	Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Nucleation Regulation Of Cellular Component Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Polymerization Regulation Of Protein Complex Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Projection Organization Immune Response-regulating Signaling Pathway Actin Polymerization Or Depolymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Protein Polymerization Chemotaxis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Protein Localization To Cell Leading Edge Spindle Assembly Involved In Female Meiosis I Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Meiotic Nuclear Division
Tagcloud ?			10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Difference) ?			10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Intersection) ?