ARPC4 and METTL21A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARPC4	METTL21A
Description		actin related protein 2/3 complex subunit 4	methyltransferase 21A, HSPA lysine
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Actin Cytoskeleton Site Of Double-strand Break Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation	Protein Methylation Methylation Negative Regulation Of Protein Folding
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Protein methylation
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	14 interacting genes: ARPC4 ATRIP FAM200C HSPA1A HSPA5 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZNF620 ZNF655 ZRANB1
Entrez ID		10093	151194
HPRD ID		10368	14090
Ensembl ID		ENSG00000241553	ENSG00000144401
Uniprot IDs		P59998	C9JES0 H7BXH9 Q8WXB1
PDB IDs		6UHC 6YW6 6YW7 8P94	4LEC
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Actin Filament Organization Actin Cytoskeleton Actin Binding Structural Constituent Of Cytoskeleton Supramolecular Fiber Organization Actin Filament Binding Site Of Double-strand Break Focal Adhesion Actin Polymerization-dependent Cell Motility Lamellipodium Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Chromosome Movement Towards Spindle Pole Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Cytoskeleton Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Spindle Localization Meiotic Cytokinesis Regulation Of Cell Projection Assembly Extracellular Exosome Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Asymmetric Cell Division Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Regulation Of Protein-containing Complex Assembly Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Cell Motility Growth Cone Leading Edge Tubulobulbar Complex Actin Polymerization Or Depolymerization Cell Leading Edge Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Type II Interferon Negative Regulation Of Membrane Tubulation
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