ARPC4 and ARPC5L

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (cross-linking study, cross-linking study, cross-linking study, biochemical, cross-linking study)
HPRD (two hybrid)

		ARPC4	ARPC5L
Description		actin related protein 2/3 complex subunit 4	actin related protein 2/3 complex subunit 5 like
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Actin Cytoskeleton Site Of Double-strand Break Cell Projection Extracellular Exosome	Cytoplasm Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Cortical Cytoskeleton Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Actin Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation	Cell Migration Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	3 interacting genes: ARPC4 GADD45G SHANK3
Entrez ID		10093	81873
HPRD ID		10368	12490
Ensembl ID		ENSG00000241553	ENSG00000136950
Uniprot IDs		P59998	A0A024R897 B3KPC7 Q9BPX5
PDB IDs		6UHC 6YW6 6YW7 8P94	6YW6 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Actin Filament Organization Actin Cytoskeleton Actin Binding Structural Constituent Of Cytoskeleton Supramolecular Fiber Organization Actin Filament Binding Site Of Double-strand Break Focal Adhesion Actin Polymerization-dependent Cell Motility Lamellipodium Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Chromosome Movement Towards Spindle Pole Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Cytoskeleton Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Spindle Localization Meiotic Cytokinesis Regulation Of Cell Projection Assembly Extracellular Exosome Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Asymmetric Cell Division Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Regulation Of Protein-containing Complex Assembly Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Cell Motility Growth Cone Leading Edge Tubulobulbar Complex Actin Polymerization Or Depolymerization Cell Leading Edge Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Type II Interferon Negative Regulation Of Membrane Tubulation	Actin Binding Arp2/3 Protein Complex Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Specialization Assembly Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Regulation Of Long-term Synaptic Depression Mechanosensory Behavior Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Positive Regulation Of Long-term Synaptic Potentiation Actin Nucleation Positive Regulation Of P38MAPK Cascade Postsynaptic Specialization Organization Regulation Of Long-term Neuronal Synaptic Plasticity Actin Filament Polymerization Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Binding Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Organization Cell Volume Homeostasis Negative Regulation Of Actin Filament Bundle Assembly Forebrain Neuron Differentiation Positive Regulation Of Dendritic Spine Development Regulation Of P38MAPK Cascade Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Regulation Of Dendritic Spine Morphogenesis Postsynapse Organization Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Receptor Clustering
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