ADAP2 and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 18298663)
0

Data Source:
BioGRID (pull down)

		ADAP2	RANBP9
Description		ArfGAP with dual PH domains 2	RAN binding protein 9
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Envelope Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3,4-bisphosphate Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding Enzyme Binding Small GTPase Binding
	Biological Process	Heart Development	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways			L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172)	Breast cancer ( 23535729 29059683)
Interacting Genes		9 interacting genes: APP EEF1G IKBKG NCL NEDD4L PRNP RANBP9 SNCA TUBB	67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1
Entrez ID		55803	10048
HPRD ID		16357	04835
Ensembl ID		ENSG00000184060	ENSG00000010017
Uniprot IDs		Q2V6Q1 Q9NPF8	Q96S59
PDB IDs			5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Cellular Response To Copper Ion Response To Copper Ion Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Cuprous Ion Binding Regulation Of Monoatomic Ion Transmembrane Transport Nuclear Envelope Lumen Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metal Ion Transport Intracellular Copper Ion Homeostasis Negative Regulation Of Signal Transduction Copper Ion Homeostasis Inclusion Body Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Regulation Of Neurotransmitter Uptake Negative Regulation Of Cell Communication Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Metal Ion Amyloid Fibril Formation Cytoplasm Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Membrane Raft Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Synaptic Plasticity Cytosol Terminal Bouton Regulation Of Calcium Ion Transport Protein Domain Specific Binding Neuron Projection Organization Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Synapse Organization Copper Ion Binding Cellular Response To Amyloid-beta Protein-containing Complex Assembly	Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway
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