ADAP2

Description		ArfGAP with dual PH domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Envelope Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3,4-bisphosphate Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Heart Development
Pathways
Drugs
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: NUFIP2
Interacting Genes		9 interacting genes: APP EEF1G IKBKG NCL NEDD4L PRNP RANBP9 SNCA TUBB
Entrez ID		55803
HPRD ID		16357
Ensembl ID		ENSG00000184060
Uniprot IDs		Q2V6Q1 Q9NPF8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Cellular Response To Copper Ion Response To Copper Ion Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Cuprous Ion Binding Regulation Of Monoatomic Ion Transmembrane Transport Nuclear Envelope Lumen Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metal Ion Transport Intracellular Copper Ion Homeostasis Negative Regulation Of Signal Transduction Copper Ion Homeostasis Inclusion Body Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Regulation Of Neurotransmitter Uptake Negative Regulation Of Cell Communication Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Metal Ion Amyloid Fibril Formation Cytoplasm Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Membrane Raft Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Synaptic Plasticity Cytosol Terminal Bouton Regulation Of Calcium Ion Transport Protein Domain Specific Binding Neuron Projection Organization Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Synapse Organization Copper Ion Binding Cellular Response To Amyloid-beta Protein-containing Complex Assembly
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