GAS6 and MERTK

Number of citations of the paper that reports this interaction (PMID 8939948)
80

Data Source:
HPRD (in vitro)

		GAS6	MERTK
Gene Name		growth arrest-specific 6	MER proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere
	Molecular Function	Phosphatidylserine Binding Receptor Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Agonist Activity Binding, Bridging	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation Proteolysis Phagocytosis Cell Cycle Arrest Cell Adhesion Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cell Proliferation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macrophage Cytokine Production Cell Migration Peptidyl-glutamic Acid Carboxylation Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Platelet Activation Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Targeting To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process	Natural Killer Cell Differentiation Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Blood Coagulation Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet degranulation Platelet activation, signaling and aggregation Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		3 interactors: AXL MERTK TYRO3	8 interactors: BMPR2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1
Entrez ID		2621	10461
HPRD ID		02705	05269
Ensembl ID		ENSG00000183087	ENSG00000153208
Uniprot IDs		Q14393	E9PHX8 Q12866
PDB IDs		1H30 2C5D	2DBJ 2P0C 3BPR 3BRB 3TCP
Enriched GO Terms of Interacting Partners?		Vagina Development Natural Killer Cell Differentiation Female Genitalia Development Apoptotic Cell Clearance Protein Kinase B Signaling Substrate Adhesion-dependent Cell Spreading Genitalia Development Natural Killer Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Platelet Activation Cell-substrate Adhesion Lymphocyte Differentiation Phagocytosis Peptidyl-tyrosine Phosphorylation Sex Differentiation Leukocyte Differentiation Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Lymphocyte Activation Blood Coagulation Hemostasis Regulation Of Cell Activation Leukocyte Activation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Hemopoiesis Secretion Gamete Generation Endocytosis Cell Activation Response To Wounding Immune System Development Cell Morphogenesis Involved In Differentiation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cell Migration Forebrain Cell Migration Cell Motility Peptidyl-amino Acid Modification Ovulation Cycle Reproduction Cell Morphogenesis	Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cellular Component Organization Response To Stress Regulation Of Cell Activation Immune System Process Positive Regulation Of Protein Metabolic Process Viral Process Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Regulation Of Endocytosis Response To Growth Factor Platelet Activation Endocytosis Positive Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Phagocytosis Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Regulation Of Signaling Negative Regulation Of Blood Pressure Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Response To External Stimulus Positive Regulation Of Immune System Process Cell Motility Positive Regulation Of Protein Modification Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Lymphocyte Activation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Signaling
Tagcloud ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Difference) ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Intersection) ?