GAS6

Description		growth arrest specific 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Receptor Ligand Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerular Filtration Protein Phosphorylation Phagocytosis Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Cell Differentiation Animal Organ Regeneration Cell-substrate Adhesion Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Interferon-alpha B Cell Chemotaxis Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Fibroblast Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Glycated hemoglobin levels ( 34059833 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 29083408) Triglyceride levels ( 32154731 32203549) Triglycerides ( 27036123 30275531)
Interacting Genes		3 interacting genes: AXL MERTK TYRO3
Entrez ID		2621
HPRD ID		02705
Ensembl ID		ENSG00000183087
Uniprot IDs		B4DZY7 Q14393
PDB IDs		1H30 2C5D 4RA0 5VXZ
Enriched GO Terms of Interacting Partners?		Vagina Development Female Genitalia Development Natural Killer Cell Differentiation Apoptotic Cell Clearance Genitalia Development Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Natural Killer Cell Activation Platelet Activation Phagocytosis Neutrophil Clearance Protein Tyrosine Kinase Activity Cell-substrate Adhesion Negative Regulation Of Lymphocyte Activation Receptor Complex Reproductive Structure Development Negative Regulation Of Leukocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Activation Ovulation Cycle Lymphocyte Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Viral Life Cycle Mononuclear Cell Differentiation Leukocyte Differentiation Secretion By Cell Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Male Gamete Generation Spermatogenesis Forebrain Cell Migration Protein Kinase Activity Secretion Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Gamete Generation Negative Regulation Of Leukocyte Apoptotic Process Leukocyte Activation Nervous System Development Positive Regulation Of Viral Process Import Into Cell Kinase Activity Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Virus Receptor Activity Regulation Of Viral Life Cycle Cell Adhesion Neuron Apoptotic Process
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