GAS6 and TYRO3

Number of citations of the paper that reports this interaction (PMID 8939948)
80

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		GAS6	TYRO3
Gene Name		growth arrest-specific 6	TYRO3 protein tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane
	Molecular Function	Phosphatidylserine Binding Receptor Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Agonist Activity Binding, Bridging	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation Proteolysis Phagocytosis Cell Cycle Arrest Cell Adhesion Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cell Proliferation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macrophage Cytokine Production Cell Migration Peptidyl-glutamic Acid Carboxylation Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Platelet Activation Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Targeting To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process	Natural Killer Cell Differentiation Cell Adhesion Signal Transduction Spermatogenesis Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Signal Transduction By Phosphorylation Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet degranulation Platelet activation, signaling and aggregation Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AXL MERTK TYRO3	20 interactors: A2M APOE AXL FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LNX1 MDFI PIK3R1 PROS1 SRC YES1
Entrez ID		2621	7301
HPRD ID		02705	02641
Ensembl ID		ENSG00000183087	ENSG00000092445
Uniprot IDs		Q14393	Q06418
PDB IDs		1H30 2C5D	1RHF
Enriched GO Terms of Interacting Partners?		Vagina Development Natural Killer Cell Differentiation Female Genitalia Development Apoptotic Cell Clearance Protein Kinase B Signaling Substrate Adhesion-dependent Cell Spreading Genitalia Development Natural Killer Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Platelet Activation Cell-substrate Adhesion Lymphocyte Differentiation Phagocytosis Peptidyl-tyrosine Phosphorylation Sex Differentiation Leukocyte Differentiation Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Lymphocyte Activation Blood Coagulation Hemostasis Regulation Of Cell Activation Leukocyte Activation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Hemopoiesis Secretion Gamete Generation Endocytosis Cell Activation Response To Wounding Immune System Development Cell Morphogenesis Involved In Differentiation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cell Migration Forebrain Cell Migration Cell Motility Peptidyl-amino Acid Modification Ovulation Cycle Reproduction Cell Morphogenesis	Platelet Activation Blood Coagulation Response To Wounding Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Regulation Of Cell Activation Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cell Activation Vesicle-mediated Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Endocytosis Cell Activation Regulation Of Lymphocyte Activation T Cell Costimulation Innate Immune Response Response To Stress Intracellular Signal Transduction Cell Migration Immune Response Regulation Of Immune Response Cell Motility Negative Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Negative Regulation Of Dendritic Cell Apoptotic Process Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Locomotion Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Nucleus Response To Peptide Hormone Defense Response Negative Regulation Of Neuron Death
Tagcloud ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin	anticoagulant ark axl brt called chinese composed ectopically eyk fc fused g1 gas6 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine ufo
Tagcloud (Difference) ?		antiapoptotic augmented ax1 cascades coincubation erk forebrain gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 windows withdrawal wortmannin	anticoagulant brt called chinese composed ectopically eyk fc fused g1 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine
Tagcloud (Intersection) ?		ark axl gas6 ufo