GAS6 and AXL

Number of citations of the paper that reports this interaction (PMID 8621659)
31

Data Source:
HPRD (in vitro)

		GAS6	AXL
Gene Name		growth arrest-specific 6	AXL receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylserine Binding Receptor Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Agonist Activity Binding, Bridging	Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation Proteolysis Phagocytosis Cell Cycle Arrest Cell Adhesion Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cell Proliferation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macrophage Cytokine Production Cell Migration Peptidyl-glutamic Acid Carboxylation Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Platelet Activation Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Targeting To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Spermatogenesis Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet degranulation Platelet activation, signaling and aggregation Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AXL MERTK TYRO3	21 interactors: ADAM10 CBL FBXO25 GAS6 GRB2 IL15RA IL2RG LCK NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		2621	558
HPRD ID		02705	00171
Ensembl ID		ENSG00000183087	ENSG00000167601
Uniprot IDs		Q14393	M0R0W6 P30530
PDB IDs		1H30 2C5D	2C5D
Enriched GO Terms of Interacting Partners?		Vagina Development Natural Killer Cell Differentiation Female Genitalia Development Apoptotic Cell Clearance Protein Kinase B Signaling Substrate Adhesion-dependent Cell Spreading Genitalia Development Natural Killer Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Platelet Activation Cell-substrate Adhesion Lymphocyte Differentiation Phagocytosis Peptidyl-tyrosine Phosphorylation Sex Differentiation Leukocyte Differentiation Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Lymphocyte Activation Blood Coagulation Hemostasis Regulation Of Cell Activation Leukocyte Activation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Hemopoiesis Secretion Gamete Generation Endocytosis Cell Activation Response To Wounding Immune System Development Cell Morphogenesis Involved In Differentiation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cell Migration Forebrain Cell Migration Cell Motility Peptidyl-amino Acid Modification Ovulation Cycle Reproduction Cell Morphogenesis	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Growth Factor Blood Coagulation Hemostasis Cellular Response To Organic Substance Response To Peptide Hormone Cellular Response To Organonitrogen Compound Locomotion Response To Organic Substance Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Insulin Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Cell Migration Wound Healing Movement Of Cell Or Subcellular Component Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Signal Transduction Cell Motility Response To Insulin Response To Wounding Regulation Of Phosphorylation Immune System Process Signaling Platelet Activation Cell Communication Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin