TTC17 and BMPR1B

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		TTC17	BMPR1B
Description		tetratricopeptide repeat domain 17	bone morphogenetic protein receptor type 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Cell Projection Organization Actin Filament Polymerization Cilium Organization	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs			Fostamatinib
Diseases			Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Birth length ( 25281659) Fibrinogen levels ( 26561523 28107422) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30578418 30224653) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: ACVR1 BMPR1B DSCAM SMURF1	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		55761	658
HPRD ID		15582	04457
Ensembl ID		ENSG00000052841	ENSG00000138696
Uniprot IDs		A0A994J3X0 Q49A97 Q96AE7	A8KAE3 O00238
PDB IDs			3MDY
Enriched GO Terms of Interacting Partners?		SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I BMP Signaling Pathway BMP Receptor Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Differentiation Regulation Of Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Protein Tyrosine Kinase Binding Positive Regulation Of Developmental Process Positive Regulation Of Bone Mineralization Neuronal Cell Body Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Development Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Regulation Of Cell Differentiation Dorsal/ventral Pattern Formation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Positive Regulation Of Axonogenesis Regulation Of Axon Extension Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Endocardial Cushion Cell Fate Commitment Engulfment Of Target By Autophagosome Regulation Of Ossification Osteoblast Differentiation Cell Differentiation Regulation Of Developmental Process Regulation Of Axonogenesis Positive Regulation Of Determination Of Dorsal Identity Regulation Of Osteoblast Differentiation Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Developmental Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Multicellular Organismal Process BMP Receptor Complex Ovarian Cumulus Expansion Neuron Projection Guidance Axon Guidance	Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration
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