FERMT3 and ANKRD29

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FERMT3	ANKRD29
Name		FERM domain containing kindlin 3	ankyrin repeat domain 29
Structure			No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome Anchoring Junction	None
	Molecular Function	Integrin Binding Protein Binding Lipid Binding	Protein Binding
	Biological Process	Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation	None
Pathways		Platelet degranulation	None
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency	None
GWAS		Attention deficit hyperactivity disorder ( 21784300 ) Crohn's disease ( 28067908 ) Fruit consumption ( 32066663 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 )	Amyotrophic lateral sclerosis (sporadic) ( 24256812 )
Interacting Genes		11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15	10 interacting genes: CABP2 CRACR2A FAM90A1 FERMT3 GTF2H5 GYPA HLCS MRPL53 RABGEF1 USP32
Entrez ID		83706	147463
HPRD ID		07440	12464
Ensembl ID		ENSG00000149781	ENSG00000154065
Uniprot IDs		F5H3I6 Q86UX7	Q8N6D5
PDB IDs		2YS3 6V97 6V9G 7C3M	Not available
GO Terms Enriched among Interactors		Anchoring Junction Focal Adhesion Regulation Of Spontaneous Synaptic Transmission Integrin Binding Cell Adhesion Regulation Of Neurotransmitter Uptake Cell-substrate Adhesion Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Adhesion Heterotypic Cell-cell Adhesion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Positive Regulation Of Intracellular Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substrate Adhesion-dependent Cell Spreading Myoblast Fate Specification Integrin Alpha7-beta1 Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex Visual Behavior Glial Cell Development Synaptic Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process	None