PRKACG and HMGN1

Number of citations of the paper that reports this interaction (PMID 11438671)
28

Data Source:
BioGRID (enzymatic study)

		PRKACG	HMGN1
Gene Name		protein kinase, cAMP-dependent, catalytic, gamma	high mobility group nucleosome binding domain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Ciliary Base	Chromatin Nucleus Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Activity ATP Binding	DNA Binding Nucleosomal DNA Binding
	Biological Process	Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CDK17 CETP HMGN1 TNP1 TNP2	17 interactors: BTG2 EP300 HMGN2 IRF2 LIG4 NFE2 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ
Entrez ID		5568	3150
HPRD ID		01483	01231
Ensembl ID		ENSG00000165059	ENSG00000205581
Uniprot IDs		P22612	A6NGZ2 P05114 Q6NSG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Single Fertilization Male Pronucleus Assembly Fertilization Triglyceride Transport Post-embryonic Camera-type Eye Morphogenesis Pyrimidine Dimer Repair By Nucleotide-excision Repair Penetration Of Zona Pellucida Post-embryonic Organ Morphogenesis Very-low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Post-embryonic Camera-type Eye Development Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Elongation Low-density Lipoprotein Particle Remodeling Response To UV-C Pyrimidine Dimer Repair Nucleosome Disassembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To UV-B Reverse Cholesterol Transport Spermatogenesis Regulation Of Development, Heterochronic Male Gamete Generation Single Strand Break Repair Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Acrosome Reaction DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Spermatid Nucleus Differentiation Gamete Generation Histone Exchange Chromatin Silencing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Chromatin Organization Transcription-coupled Nucleotide-excision Repair Binding Of Sperm To Zona Pellucida Regulation Of Macrophage Derived Foam Cell Differentiation Calcium Ion-dependent Exocytosis Anion Homeostasis Sexual Reproduction Multicellular Organismal Reproductive Process Sperm-egg Recognition Regulation Of DNA-templated Transcription, Elongation Phosphatidylcholine Metabolic Process	Response To Stress Defense Response Histone Phosphorylation Immune Response Response To Stimulus Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Chromosome Organization Immune System Process Chromatin Organization Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Neurotrophin TRK Receptor Signaling Pathway Hemostasis Neurotrophin Signaling Pathway Response To Interleukin-1 Triglyceride Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Innate Immune Response Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Acylglycerol Catabolic Process Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Chemotaxis Chromatin Modification Energy Reserve Metabolic Process Histone H3-S10 Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Phosphorylation Response To Wounding ERBB Signaling Pathway Histone Modification Anatomical Structure Development Regulation Of Cellular Amino Acid Metabolic Process Activation Of Phospholipase C Activity Neutrophil Chemotaxis Neutrophil Migration Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Phospholipase C Activity
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Intersection) ?