PRKACG and CETP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRKACG	CETP
Gene Name		protein kinase, cAMP-dependent, catalytic, gamma	cholesteryl ester transfer protein, plasma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Ciliary Base	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	CAMP-dependent Protein Kinase Activity ATP Binding	Lipid Transporter Activity Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Triglyceride Binding Phosphatidylcholine Binding
	Biological Process	Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus	Triglyceride Metabolic Process Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Phosphatidylcholine Metabolic Process Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Lipoprotein metabolism HDL-mediated lipid transport LDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport Orphan transporters
Drugs
Diseases
GWAS			Age-related macular degeneration ( 20385819 23455636 21665990) Biochemical measures ( 19260141) Cardiovascular disease risk factors ( 21943158 20838585) Cholesterol ( 20066028) Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 23726366 20031538 19359809 20031564 21909109 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Triglycerides ( 17463246 20686565) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		5 interactors: CDK17 CETP HMGN1 TNP1 TNP2	5 interactors: APOA1 ARPC3 EWSR1 LPL PRKACG
Entrez ID		5568	1071
HPRD ID		01483	00325
Ensembl ID		ENSG00000165059	ENSG00000087237
Uniprot IDs		P22612	P11597
PDB IDs			2OBD 4EWS 4F2A
Enriched GO Terms of Interacting Partners?		Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Single Fertilization Male Pronucleus Assembly Fertilization Triglyceride Transport Post-embryonic Camera-type Eye Morphogenesis Pyrimidine Dimer Repair By Nucleotide-excision Repair Penetration Of Zona Pellucida Post-embryonic Organ Morphogenesis Very-low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Post-embryonic Camera-type Eye Development Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Elongation Low-density Lipoprotein Particle Remodeling Response To UV-C Pyrimidine Dimer Repair Nucleosome Disassembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To UV-B Reverse Cholesterol Transport Spermatogenesis Regulation Of Development, Heterochronic Male Gamete Generation Single Strand Break Repair Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Acrosome Reaction DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Spermatid Nucleus Differentiation Gamete Generation Histone Exchange Chromatin Silencing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Chromatin Organization Transcription-coupled Nucleotide-excision Repair Binding Of Sperm To Zona Pellucida Regulation Of Macrophage Derived Foam Cell Differentiation Calcium Ion-dependent Exocytosis Anion Homeostasis Sexual Reproduction Multicellular Organismal Reproductive Process Sperm-egg Recognition Regulation Of DNA-templated Transcription, Elongation Phosphatidylcholine Metabolic Process	Triglyceride Catabolic Process Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Glycerolipid Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Triglyceride Metabolic Process Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Lipid Homeostasis Isoprenoid Metabolic Process Cellular Lipid Catabolic Process Negative Regulation Of Interleukin-1 Beta Secretion Chemical Homeostasis Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Chylomicron Remodeling Cellular Lipid Metabolic Process Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Interleukin-1 Secretion Lipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Sequestering Of Triglyceride Protein Oxidation Lipid Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cellular Component Biogenesis Very-low-density Lipoprotein Particle Remodeling Homeostatic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Response To Light Stimulus Response To Stress Regulation Of Actin Cytoskeleton Organization Regulation Of Cholesterol Esterification
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Intersection) ?