PRKACG and TNP1

Number of citations of the paper that reports this interaction (PMID 9837753)
2

Data Source:
BioGRID (enzymatic study)

		PRKACG	TNP1
Gene Name		protein kinase, cAMP-dependent, catalytic, gamma	transition protein 1 (during histone to protamine replacement)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Ciliary Base	Nucleosome Male Germ Cell Nucleus
	Molecular Function	CAMP-dependent Protein Kinase Activity ATP Binding	DNA Binding
	Biological Process	Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Chromatin Silencing Multicellular Organismal Development Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Sexual Reproduction Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Permanent tooth development ( 21931568)
Protein-Protein Interactions		5 interactors: CDK17 CETP HMGN1 TNP1 TNP2	9 interactors: CSNK2A1 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2
Entrez ID		5568	7141
HPRD ID		01483	01830
Ensembl ID		ENSG00000165059	ENSG00000118245
Uniprot IDs		P22612	P09430 Q4ZG82
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Single Fertilization Male Pronucleus Assembly Fertilization Triglyceride Transport Post-embryonic Camera-type Eye Morphogenesis Pyrimidine Dimer Repair By Nucleotide-excision Repair Penetration Of Zona Pellucida Post-embryonic Organ Morphogenesis Very-low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Post-embryonic Camera-type Eye Development Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Elongation Low-density Lipoprotein Particle Remodeling Response To UV-C Pyrimidine Dimer Repair Nucleosome Disassembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To UV-B Reverse Cholesterol Transport Spermatogenesis Regulation Of Development, Heterochronic Male Gamete Generation Single Strand Break Repair Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Acrosome Reaction DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Spermatid Nucleus Differentiation Gamete Generation Histone Exchange Chromatin Silencing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Chromatin Organization Transcription-coupled Nucleotide-excision Repair Binding Of Sperm To Zona Pellucida Regulation Of Macrophage Derived Foam Cell Differentiation Calcium Ion-dependent Exocytosis Anion Homeostasis Sexual Reproduction Multicellular Organismal Reproductive Process Sperm-egg Recognition Regulation Of DNA-templated Transcription, Elongation Phosphatidylcholine Metabolic Process	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase Activity Cellular Response To Hormone Stimulus Activation Of Protein Kinase A Activity Regulation Of Hormone Secretion Regulation Of Phospholipase Activity Wound Healing Positive Regulation Of Lipase Activity Triglyceride Catabolic Process Response To Wounding Acylglycerol Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Energy Reserve Metabolic Process Renal Water Homeostasis Regulation Of Protein Secretion Glucose Metabolic Process System Development Cellular Lipid Catabolic Process Generation Of Precursor Metabolites And Energy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Hormone Response To Peptide Hormone Cellular Response To Glucagon Stimulus Cellular Lipid Metabolic Process Histone H3-T6 Phosphorylation Response To Peptide Water Transport Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Multicellular Organismal Development Cellular Response To Organic Substance Fluid Transport Hexose Metabolic Process Multicellular Organismal Water Homeostasis Anatomical Structure Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Glucagon Gluconeogenesis Negative Regulation Of Collagen Biosynthetic Process Fatty Acid Transport Signal Transduction Lipid Catabolic Process Monosaccharide Metabolic Process Water Homeostasis
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny typed vil1 visceral
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny typed vil1 visceral
Tagcloud (Intersection) ?