PRKACG and CDK17

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRKACG	CDK17
Description		protein kinase cAMP-activated catalytic subunit gamma	cyclin dependent kinase 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol CAMP-dependent Protein Kinase Complex Ciliary Base	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Renal Water Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Protein Phosphorylation Regulation Of Cell Cycle Phase Transition
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Diastolic blood pressure ( 30224653) Manganese levels ( 26025379) Phospholipid levels (plasma) ( 22359512)
Interacting Genes		4 interacting genes: CDK17 CETP TNP1 TNP2	11 interacting genes: APP BICDL2 CDKN2B DPY30 EPHA2 PRKACG TDRD7 TGFBR1 UBC YWHAG YWHAZ
Entrez ID		5568	5128
HPRD ID		01483	09141
Ensembl ID		ENSG00000165059	ENSG00000059758
Uniprot IDs		P22612	Q00537
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Processing Sperm DNA Condensation Positive Regulation Of Protein Maturation Regulation Of Protein Processing Regulation Of Protein Maturation Sperm DNA Decondensation Nucleosome Triglyceride Transport Triglyceride Binding Positive Regulation Of Proteolysis Spermatid Nucleus Elongation Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Differentiation Penetration Of Zona Pellucida Low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Phospholipid Transporter Activity Positive Regulation Of Phospholipid Transport Reverse Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sexual Reproduction Single Strand Break Repair Regulation Of Proteolysis Acrosome Reaction High-density Lipoprotein Particle Remodeling Male Gamete Generation Nucleosome Disassembly Spermatogenesis High-density Lipoprotein Particle Cholesterol Transfer Activity Gamete Generation Protein-DNA Complex Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activity Phosphatidylcholine Binding Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Chromosome Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Efflux Cholesterol Binding Male Germ Cell Nucleus Positive Regulation Of Protein Metabolic Process	Positive Regulation Of Apoptotic Signaling Pathway Response To Nutrient Levels Response To Growth Factor Intracellular Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Animal Organ Development Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Molecular Function Activator Activity Receptor Complex Cellular Response To Nutrient Levels Growth Factor Binding Notochord Cell Development Endothelial Cell Proliferation Vesicle Cellular Response To Glucose Starvation Protein Sequestering Activity Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of ERK1 And ERK2 Cascade TORC1 Signaling Negative Regulation Of TORC1 Signaling Response To Transforming Growth Factor Beta Defense Response To Bacterium Angiogenesis Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Apoptosome Anatomical Structure Formation Involved In Morphogenesis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Hematopoietic Or Lymphoid Organ Development Negative Regulation Of Lymphangiogenesis Notochord Formation
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