PRKACG and TNP2

Number of citations: 0 (PubMedID 9837753)
Data Source: BioGRID (enzymatic study)

		PRKACG	TNP2
Name		protein kinase cAMP-activated catalytic subunit gamma	transition protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol CAMP-dependent Protein Kinase Complex Ciliary Base	Nucleosome Nucleus Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Renal Water Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Spermatogenesis Acrosome Reaction Penetration Of Zona Pellucida Positive Regulation Of Protein Processing Cell Differentiation Sperm DNA Condensation
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
GWAS		Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 )	Asthma ( 31959851 ) Bulimia nervosa ( 23568457 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Multiple sclerosis ( 22190364 ) Type 1 diabetes ( 18978792 )
Interacting Genes		4 interacting genes: CDK17 CETP TNP1 TNP2	17 interacting genes: APPBP2 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 MDFI NOTCH2NLA PRKACA PRKACB PRKACG PRKCA
Entrez ID		5568	7142
HPRD ID		01483	01831
Ensembl ID		ENSG00000165059	ENSG00000178279
Uniprot IDs		P22612	Q05952 Q4VB56
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Protein Processing Sperm DNA Condensation Positive Regulation Of Protein Maturation Regulation Of Protein Processing Regulation Of Protein Maturation Sperm DNA Decondensation Nucleosome Triglyceride Transport Triglyceride Binding Positive Regulation Of Proteolysis Spermatid Nucleus Elongation Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Differentiation Penetration Of Zona Pellucida Low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Phospholipid Transporter Activity Positive Regulation Of Phospholipid Transport Reverse Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sexual Reproduction Single Strand Break Repair Regulation Of Proteolysis Acrosome Reaction High-density Lipoprotein Particle Remodeling Male Gamete Generation Nucleosome Disassembly Spermatogenesis High-density Lipoprotein Particle Cholesterol Transfer Activity Gamete Generation Protein-DNA Complex Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activity Phosphatidylcholine Binding Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Chromosome Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Efflux Cholesterol Binding Male Germ Cell Nucleus Positive Regulation Of Protein Metabolic Process	Keratin Filament Intermediate Filament CAMP-dependent Protein Kinase Activity CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Renal System Process Ciliary Base Response To Fluid Shear Stress Cytosol Multicellular Organismal-level Chemical Homeostasis Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Smoothened Signaling Pathway Protein Kinase Activity Regulation Of Protein Processing Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Maturation Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Regulation Of Body Fluid Levels Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Smoothened Signaling Pathway TOR Signaling Positive Regulation Of Insulin Secretion Neural Tube Closure