PRKACG and TNP2

Number of citations of the paper that reports this interaction (PMID 9837753)
2

Data Source:
BioGRID (enzymatic study)

		PRKACG	TNP2
Gene Name		protein kinase, cAMP-dependent, catalytic, gamma	transition protein 2 (during histone to protamine replacement)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Ciliary Base	Nucleosome Nucleus
	Molecular Function	CAMP-dependent Protein Kinase Activity ATP Binding	DNA Binding Metal Ion Binding
	Biological Process	Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus	Multicellular Organismal Development Spermatogenesis Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Cell Differentiation Sperm Motility
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Multiple sclerosis ( 22190364) Type 1 diabetes ( 18978792)
Protein-Protein Interactions		5 interactors: CDK17 CETP HMGN1 TNP1 TNP2	11 interactors: KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MDFI NOTCH2NL PRKACA PRKACB PRKACG PRKCA
Entrez ID		5568	7142
HPRD ID		01483	01831
Ensembl ID		ENSG00000165059	ENSG00000178279
Uniprot IDs		P22612	Q05952 Q4VB56
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Single Fertilization Male Pronucleus Assembly Fertilization Triglyceride Transport Post-embryonic Camera-type Eye Morphogenesis Pyrimidine Dimer Repair By Nucleotide-excision Repair Penetration Of Zona Pellucida Post-embryonic Organ Morphogenesis Very-low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Post-embryonic Camera-type Eye Development Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Elongation Low-density Lipoprotein Particle Remodeling Response To UV-C Pyrimidine Dimer Repair Nucleosome Disassembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To UV-B Reverse Cholesterol Transport Spermatogenesis Regulation Of Development, Heterochronic Male Gamete Generation Single Strand Break Repair Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Acrosome Reaction DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Spermatid Nucleus Differentiation Gamete Generation Histone Exchange Chromatin Silencing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Chromatin Organization Transcription-coupled Nucleotide-excision Repair Binding Of Sperm To Zona Pellucida Regulation Of Macrophage Derived Foam Cell Differentiation Calcium Ion-dependent Exocytosis Anion Homeostasis Sexual Reproduction Multicellular Organismal Reproductive Process Sperm-egg Recognition Regulation Of DNA-templated Transcription, Elongation Phosphatidylcholine Metabolic Process	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Activation Of Protein Kinase A Activity Triglyceride Catabolic Process Energy Reserve Metabolic Process Acylglycerol Catabolic Process Renal Water Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Protein Transport Cellular Response To Glucagon Stimulus Neurotrophin TRK Receptor Signaling Pathway Water Transport Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Neurotrophin Signaling Pathway Histone H3-T6 Phosphorylation Fluid Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Water Homeostasis Regulation Of Hormone Secretion Response To Glucagon Gluconeogenesis Regulation Of Kinase Activity Activation Of Protein Kinase Activity Regulation Of Protein Localization Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Phosphorylation Hexose Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Regulation Of Protein Secretion Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Metabolic Process Renal System Process Positive Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	669t adapt adaptations boars breed breeds coincide colocalizes colour concordant domesticated domestication ednrb gpr149 implied indigenous jmjd1c litter massively melanocyte mitf pigs prm1 prm2 selections spotted sweep synonymous tongcheng
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	669t adapt adaptations boars breed breeds coincide colocalizes colour concordant domesticated domestication gpr149 implied indigenous jmjd1c litter massively melanocyte mitf pigs prm1 prm2 selections spotted sweep synonymous tongcheng
Tagcloud (Intersection) ?		ednrb