NPLOC4 and NEDD8

Number of citations of the paper that reports this interaction (PMID 24019527)
1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NPLOC4	NEDD8
Gene Name		nuclear protein localization 4 homolog (S. cerevisiae)	neural precursor cell expressed, developmentally down-regulated 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Golgi Organization ER-associated Ubiquitin-dependent Protein Catabolic Process Membrane Fusion	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Eye color traits ( 20463881)
Protein-Protein Interactions		6 interactors: GZMK NEDD8 RAF1 UBC UFD1L VCP	34 interactors: AHR ANK1 ARIH1 ARIH2 CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B CUL5 DCUN1D1 DNMT3B NAE1 NPLOC4 NUB1 PARP1 PSMD4 PTK2 RPL11 SENP8 SMURF1 TP53 UBA2 UBA3 UBE2F UBE2K UBE2M UBXN7 UCHL1 UCHL3 UFD1L
Entrez ID		55666	4738
HPRD ID		06975	04412
Ensembl ID		ENSG00000182446	ENSG00000129559
Uniprot IDs		Q8TAT6	Q15843
PDB IDs			1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Death-inducing Signaling Complex Assembly Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Catabolic Process Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Programmed Cell Death Regulation Of Protein Deubiquitination Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Response To Organic Substance Protein Hexamerization Response To Abiotic Stimulus	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Protein Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Neddylation Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Deneddylation Apoptotic Process Mitotic Cell Cycle Programmed Cell Death Regulation Of Protein Catabolic Process Cell Death Death Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Apoptotic Signaling Pathway Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Protein Monoubiquitination Positive Regulation Of Proteolysis
Tagcloud ?			activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Difference) ?			activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Intersection) ?