NEDD8 and RPL11

Number of citations of the paper that reports this interaction (PMID 19713960)
30

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NEDD8	RPL11
Gene Name		neural precursor cell expressed, developmentally down-regulated 8	ribosomal protein L11
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Nucleolus Cytosol Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Neddylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: AHR ANK1 ARIH1 ARIH2 CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B CUL5 DCUN1D1 DNMT3B NAE1 NPLOC4 NUB1 PARP1 PSMD4 PTK2 RPL11 SENP8 SMURF1 TP53 UBA2 UBA3 UBE2F UBE2K UBE2M UBXN7 UCHL1 UCHL3 UFD1L	14 interactors: ARFGAP1 BLMH C12orf5 CAMK2B HP IGF1R KRT40 KRTAP10-7 LIG4 MDM2 NEDD8 PAIP2 PML STAT3
Entrez ID		4738	6135
HPRD ID		04412	10364
Ensembl ID		ENSG00000129559	ENSG00000142676
Uniprot IDs		Q15843	P62913 Q5VVD0
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP	3J3B
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Protein Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Neddylation Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Deneddylation Apoptotic Process Mitotic Cell Cycle Programmed Cell Death Regulation Of Protein Catabolic Process Cell Death Death Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Apoptotic Signaling Pathway Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Protein Monoubiquitination Positive Regulation Of Proteolysis	Regulation Of Cell Death Response To Gamma Radiation Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Ionizing Radiation Response To Radiation Response To Inorganic Substance Response To Stimulus Regulation Of Cell Cycle Process Response To Organic Substance Protein Localization To Nucleus Viral Process Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Acute-phase Response Positive Regulation Of Cell Death Negative Regulation Of Reactive Oxygen Species Metabolic Process Immune Response Defense Response Regulation Of Muscle Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Catalytic Activity Regulation Of Cell Proliferation Cellular Response To Peptide Response To Metal Ion Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Translation In Response To Oxidative Stress DNA Ligation Involved In DNA Recombination Cellular Response To UV-C Inactivation Of MAPKK Activity Cellular Response To Vitamin B1 Inhibitory G-protein Coupled Receptor Phosphorylation Somatic Stem Cell Maintenance Cellular Response To Stress Proteolysis Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint
Tagcloud ?		activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin	actinomycin biogenesis blunted blunting blunts caffeine chemotherapeutics combinatorial connected destabilize glioma indeed insults ly294 master mechanistic mimicked mtor nucleolar osteosarcoma pp242 rapamycin ribosome simultaneous stabilization temsirolimus triggered whereby wortmannin
Tagcloud (Difference) ?		activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin	actinomycin biogenesis blunted blunting blunts caffeine chemotherapeutics combinatorial connected destabilize glioma indeed insults ly294 master mechanistic mimicked mtor nucleolar osteosarcoma pp242 rapamycin ribosome simultaneous stabilization temsirolimus triggered whereby wortmannin
Tagcloud (Intersection) ?