NEDD8 and DCUN1D1

Number of citations of the paper that reports this interaction (PMID 18826954)
22

Data Source:
BioGRID (pull down)

		NEDD8	DCUN1D1
Gene Name		neural precursor cell expressed, developmentally down-regulated 8	DCN1, defective in cullin neddylation 1, domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Neddylation	Biological_process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: AHR ANK1 ARIH1 ARIH2 CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B CUL5 DCUN1D1 DNMT3B NAE1 NPLOC4 NUB1 PARP1 PSMD4 PTK2 RPL11 SENP8 SMURF1 TP53 UBA2 UBA3 UBE2F UBE2K UBE2M UBXN7 UCHL1 UCHL3 UFD1L	21 interactors: ARRDC3 AURKB CALM1 CAND1 CUL2 CUL3 CUL4A CUL4B DAZAP2 LAPTM5 LZTS2 NEDD4 NEDD8 RHOA RNF11 SMAD2 TP53BP2 TRIM39 TRIM54 UBE2F VPS37B
Entrez ID		4738	54165
HPRD ID		04412	12067
Ensembl ID		ENSG00000129559
Uniprot IDs		Q15843	C9JVE2 Q96GG9
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP	3TDU 3TDZ
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Protein Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Neddylation Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Deneddylation Apoptotic Process Mitotic Cell Cycle Programmed Cell Death Regulation Of Protein Catabolic Process Cell Death Death Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Apoptotic Signaling Pathway Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Protein Monoubiquitination Positive Regulation Of Proteolysis	Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Cytokinesis Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Cellular Response To Light Stimulus Cellular Protein Modification Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Cytokinesis Cellular Response To Radiation Catabolic Process Protein Monoubiquitination Cell Cycle Cleavage Furrow Formation Positive Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Proteolysis Cellular Response To UV Protein Neddylation Mitotic Cell Cycle Regulation Of Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Spindle Midzone Assembly Cellular Protein Metabolic Process Spindle Assembly Regulation Of Cell Division Regulation Of Signaling Developmental Process Viral Process Protein Metabolic Process Cytokinesis Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Protein Complex Assembly Cell Cycle Process Positive Regulation Of Cell Division Response To Light Stimulus Spindle Organization Cellular Protein Complex Assembly
Tagcloud ?		activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin	achilles adapter adapters amplicons amplifications amplified atlas backgrounds bioinformatics datasets driver druggable emphasis fgfr frs2 gistic2 grb7 hedgehog kras narrowed nsd3 pik3ca projects putative referencing shrna spanning tailoring tcga
Tagcloud (Difference) ?		activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin	achilles adapter adapters amplicons amplifications amplified atlas backgrounds bioinformatics datasets driver druggable emphasis fgfr frs2 gistic2 grb7 hedgehog kras narrowed nsd3 pik3ca projects putative referencing shrna spanning tailoring tcga
Tagcloud (Intersection) ?