ZYG11B and TLR6

		ZYG11B	TLR6
Description		zyg-11 family member B, cell cycle regulator	toll like receptor 6
Image
GO Annotations	Cellular Component	Cytoplasm Cul2-RING Ubiquitin Ligase Complex	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Diacyl Lipopeptide Binding Identical Protein Binding Protein Heterodimerization Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Response To Bacterial Lipoprotein Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand RSV-host interactions
Drugs			Pam2csk4
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Interacting Genes		4 interacting genes: CUL2 ELOB ELOC GBF1	4 interacting genes: BTK HRAS TLR2 TRAP1
Entrez ID		79699	10333
HPRD ID		13356	05656
Ensembl ID		ENSG00000162378	ENSG00000174130
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	B2R933 Q9Y2C9
PDB IDs		7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2	4OM7
Enriched GO Terms of Interacting Partners?		Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway	Positive Regulation Of Type I Hypersensitivity Regulation Of Phagocytosis Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Activation Of Immune Response Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Affinity Maturation Immune Response-activating Signaling Pathway Glial Cell Development GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Triacyl Lipopeptide Binding Detection Of Diacyl Bacterial Lipopeptide Translational Attenuation Defense Response To Other Organism Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Intracellular Signal Transduction Phospholipase C Activator Activity Cellular Response To Triacyl Bacterial Lipopeptide Microglia Development Positive Regulation Of Matrix Metallopeptidase Secretion Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Cellular Response To Molecule Of Fungal Origin Regulation Of Cytokine Production Detection Of Bacterial Lipoprotein
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?