ZYG11B and UCK2

		ZYG11B	UCK2
Description		zyg-11 family member B, cell cycle regulator	uridine-cytidine kinase 2
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GO Annotations	Cellular Component	Cytoplasm Cul2-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Uridine Kinase Activity ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Cytidine Kinase Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Feeding Behavior CMP Biosynthetic Process UMP Salvage CTP Salvage Response To Axon Injury Cellular Response To Oxygen Levels
Pathways			Pyrimidine salvage
Drugs			Cytidine Cytidine-5'-Triphosphate Cytidine-5'-Monophosphate Uridine 5'-triphosphate
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Multiple sclerosis ( 31604244) Testicular germ cell tumor ( 23666239 23666240 25877299 28604728 28604732)
Interacting Genes		4 interacting genes: CUL2 ELOB ELOC GBF1
Entrez ID		79699	7371
HPRD ID		13356	01882
Ensembl ID		ENSG00000162378	ENSG00000143179
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	A0A2R8Y653 Q9BZX2
PDB IDs		7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2	1UDW 1UEI 1UEJ 1UFQ 1UJ2 1XRJ 6N53 6N54 6N55 6PWZ 7SQL
Enriched GO Terms of Interacting Partners?		Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process
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