ZYG11B and CFL2

		ZYG11B	CFL2
Description		zyg-11 family member B, cell cycle regulator	cofilin 2
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GO Annotations	Cellular Component	Cytoplasm Cul2-RING Ubiquitin Ligase Complex	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing
Pathways
Drugs
Diseases			Nemaline myopathy
GWAS		Monocyte percentage of white cells ( 32888494)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Takayasu arteritis ( 33308445)
Interacting Genes		4 interacting genes: CUL2 ELOB ELOC GBF1	12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I
Entrez ID		79699	1073
HPRD ID		13356	03262
Ensembl ID		ENSG00000162378	ENSG00000165410
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	Q549N0 Q9Y281
PDB IDs		7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2	7M0G 7U8K
Enriched GO Terms of Interacting Partners?		Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway	Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization
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