ZYG11B and NDC1

		ZYG11B	NDC1
Description		zyg-11 family member B, cell cycle regulator	NDC1 transmembrane nucleoporin
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GO Annotations	Cellular Component	Cytoplasm Cul2-RING Ubiquitin Ligase Complex	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Plasma Membrane Actin Cytoskeleton Membrane Nuclear Membrane Nuclear Pore Transmembrane Ring
	Molecular Function	Protein Binding	Structural Constituent Of Nuclear Pore Protein-macromolecule Adaptor Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Nucleocytoplasmic Transport Nuclear Pore Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Protein Transport MRNA Transport Nuclear Pore Complex Assembly Nuclear Pore Localization
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Response to antidepressants and depression ( 27622933)
Interacting Genes		4 interacting genes: CUL2 ELOB ELOC GBF1	2 interacting genes: NUP93 UBC
Entrez ID		79699	55706
HPRD ID		13356	08547
Ensembl ID		ENSG00000162378	ENSG00000058804
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	Q9BTX1
PDB IDs		7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2	7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway	Endocytic Vesicle Membrane Negative Regulation Of Membrane Tubulation Vesicle Scission
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