TBC1D22B and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D22B	HSD17B14
Description		TBC1 domain family member 22B	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Golgi Apparatus	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Regulation Of Cilium Assembly	Fucose Metabolic Process Lipid Metabolic Process Steroid Metabolic Process L-fucose Catabolic Process
Pathways			Estrogen biosynthesis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		55633	51171
HPRD ID		15475	16801
Ensembl ID		ENSG00000065491	ENSG00000087076
Uniprot IDs		Q9NU19	A0A140VJH8 Q9BPX1
PDB IDs		6D0S	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI 6ZR6 6ZRA 6ZT2
Enriched GO Terms of Interacting Partners?		Cytoskeleton Identical Protein Binding Cytoplasm Protein Binding Microtubule Binding Organelle Organization Regulation Of Autophagy Trans-Golgi Network Membrane Positive Regulation Of Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Golgi Organization Microtubule-based Process Centriole Replication Cytoskeleton Organization De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Microtubule Nucleation Microtubule De Novo Centriole Assembly Centriole Assembly Microtubule Organizing Center Organization Signaling Receptor Complex Adaptor Activity Supramolecular Fiber Organization Establishment Of Protein Localization Golgi Apparatus Cytosol Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Localization Positive Regulation Of Catabolic Process Microtubule Cytoskeleton Organization Protein Transport
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