TBC1D22B and LIMS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D22B	LIMS1
Description		TBC1 domain family member 22B	LIM zinc finger domain containing 1
Image
GO Annotations	Cellular Component	Golgi Apparatus	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding	Actin Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Regulation Of Cilium Assembly	Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of DNA-templated Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways			Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)	Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4	47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587
Entrez ID		55633	3987
HPRD ID		15475	03978
Ensembl ID		ENSG00000065491	ENSG00000169756
Uniprot IDs		Q9NU19	A0A8Q3WKI3 A0A8Q3WKJ2 A0A8Q3WKK6 A0A8Q3WKP0 F8WC86 P48059
PDB IDs		6D0S	1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF 7D2S 7D2T 7D2U 7LT9
Enriched GO Terms of Interacting Partners?		Cytoskeleton Identical Protein Binding Cytoplasm Protein Binding Microtubule Binding Organelle Organization Regulation Of Autophagy Trans-Golgi Network Membrane Positive Regulation Of Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Golgi Organization Microtubule-based Process Centriole Replication Cytoskeleton Organization De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Microtubule Nucleation Microtubule De Novo Centriole Assembly Centriole Assembly Microtubule Organizing Center Organization Signaling Receptor Complex Adaptor Activity Supramolecular Fiber Organization Establishment Of Protein Localization Golgi Apparatus Cytosol Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Localization Positive Regulation Of Catabolic Process Microtubule Cytoskeleton Organization Protein Transport	Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Cell-matrix Adhesion SMAD Binding Positive Regulation Of Cell Differentiation Metal Ion Binding Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Filament-based Process Integrin-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Detection Of Muscle Stretch Telethonin Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Cell Differentiation Structural Constituent Of Muscle Positive Regulation Of Stem Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Stress Fiber Assembly Regulation Of DNA-templated Transcription Integrin Activation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sarcomere Z Disc Positive Regulation Of Epithelial To Mesenchymal Transition Actinin Binding Positive Regulation Of Actin Filament Bundle Assembly Integrin Binding Cardiac Myofibril Assembly Regulation Of Actin Filament Organization Nucleus Anchoring Junction I-SMAD Binding Actin Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization
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