TBC1D22B and SPATA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D22B	SPATA2
Description		TBC1 domain family member 22B	spermatogenesis associated 2
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GO Annotations	Cellular Component	Golgi Apparatus	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Regulation Of Cilium Assembly	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 18364390 20953189 25574825)
Interacting Genes		58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4	22 interacting genes: ANKRD11 APP ATP6V1H CATSPERT CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 TBC1D22B TNIP1 TRAF2 TRIM27 UBC ZNF835
Entrez ID		55633	9825
HPRD ID		15475	09636
Ensembl ID		ENSG00000065491	ENSG00000158480
Uniprot IDs		Q9NU19	A8K0S9 B4DID4 Q9UM82
PDB IDs		6D0S	5LJM 5LJN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Identical Protein Binding Cytoplasm Protein Binding Microtubule Binding Organelle Organization Regulation Of Autophagy Trans-Golgi Network Membrane Positive Regulation Of Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Golgi Organization Microtubule-based Process Centriole Replication Cytoskeleton Organization De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Microtubule Nucleation Microtubule De Novo Centriole Assembly Centriole Assembly Microtubule Organizing Center Organization Signaling Receptor Complex Adaptor Activity Supramolecular Fiber Organization Establishment Of Protein Localization Golgi Apparatus Cytosol Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Localization Positive Regulation Of Catabolic Process Microtubule Cytoskeleton Organization Protein Transport	Microtubule-based Process Spindle Pole Pattern Recognition Receptor Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Segregation Innate Immune Response-activating Signaling Pathway Innate Immune Response Activation Of Innate Immune Response Regulation Of Metaphase Plate Congression Identical Protein Binding Regulation Of Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Serine/threonine Kinase Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus DUTP Catabolic Process DUTP Diphosphatase Activity Spindle Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Regulation Of Autophagy Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Innate Immune Response Epididymis Development Immune Response-activating Signaling Pathway TORC2 Complex Disassembly Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation MAD1 Complex Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Microtubule-based Movement Regulation Of Cytokine-mediated Signaling Pathway Cytoskeleton Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response
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