POMGNT1 and CXCL8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		POMGNT1	CXCL8
Gene Name		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	chemokine (C-X-C motif) ligand 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Protein O-linked Glycosylation	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BRCA1 CXCL8 LNX1 SOX6 ZBTB18	18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1
Entrez ID		55624	3576
HPRD ID		09493	00909
Ensembl ID		ENSG00000085998	ENSG00000169429
Uniprot IDs		F5H827 Q8WZA1	P10145
PDB IDs			1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8
Enriched GO Terms of Interacting Partners?		Embryo Development Cellular Response To Tumor Necrosis Factor Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Response To Tumor Necrosis Factor Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Indole-3-methanol Negative Regulation Of Nucleic Acid-templated Transcription Homeostasis Of Number Of Cells Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Centriole Replication Regulation Of Mesenchymal Stem Cell Differentiation Dosage Compensation By Inactivation Of X Chromosome Muscle Organ Development Oligodendrocyte Cell Fate Specification Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Protein K6-linked Ubiquitination Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Striated Muscle Tissue Development Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Muscle Tissue Development Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Negative Regulation Of Cell Cycle Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Induction Of Positive Chemotaxis Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Regulation Of Transcription From RNA Polymerase II Promoter Glial Cell Fate Commitment Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation	Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion
Tagcloud ?		176t 2059dupc boy carbohydrate concurred confirming damaging delay differing duplication dystroglycan dystroglycanopathies dystroglycanopathy dystrophy genetically glycosylation immunofluorescence involvements moiety muscular ocular platforms pomt2 premature severities silico substitution termination
Tagcloud (Difference) ?		176t 2059dupc boy carbohydrate concurred confirming damaging delay differing duplication dystroglycan dystroglycanopathies dystroglycanopathy dystrophy genetically glycosylation immunofluorescence involvements moiety muscular ocular platforms pomt2 premature severities silico substitution termination
Tagcloud (Intersection) ?