POMGNT1 and RXYLT1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		POMGNT1	RXYLT1
Description		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	ribitol xylosyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Golgi Membrane Nucleoplasm Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	Protein Binding Transferase Activity Ribitol Beta-1,4-xylosyltransferase Activity
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Brain Development Sensory Perception Of Sound Gene Expression Protein O-linked Glycosylation Via N-acetyl-galactosamine Dentate Gyrus Development Protein O-linked Glycosylation Via Mannose Protein Modification Process Myelination Localization Of Cell Basement Membrane Organization Reactive Gliosis	Protein Glycosylation Protein O-linked Glycosylation Via Mannose
Pathways		Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 core M2 glycosylations DAG1 core M1 glycosylations Matriglycan biosynthesis on DAG1	Matriglycan biosynthesis on DAG1
Drugs
Diseases		Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Body mass index ( 26426971)
Interacting Genes		14 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 GOLPH3 GOLPH3L LNX1 MBD1 RXYLT1 SOX6 TMEM237 ZBTB18	2 interacting genes: GPR3 POMGNT1
Entrez ID		55624	10329
HPRD ID		09493	12057
Ensembl ID		ENSG00000085998	ENSG00000118600
Uniprot IDs		A0A8I5KNB7 B7Z7F2 B7Z7Q4 Q8WZA1	A0A8I5KWX9 Q9Y2B1
PDB IDs		5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Cisterna Golgi Membrane Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Granulocyte Chemotaxis Phosphatidylinositol-4-phosphate Binding Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Neutrophil Migration Regulation Of Fatty Acid Biosynthetic Process MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Granulocyte Chemotaxis Ribitol Beta-1,4-xylosyltransferase Activity Positive Regulation Of Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macrophage Migration Inhibitory Factor Binding Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Interleukin-8 Receptor Binding Retrograde Transporter Complex, Golgi To ER Golgi Vesicle Transport Golgi Cisterna Membrane Asymmetric Golgi Ribbon Formation Positive Regulation Of Establishment Of Protein Localization	Sphingosine-1-phosphate Receptor Activity Sphingolipid Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Reactive Gliosis Protein O-linked Glycosylation Via Mannose Neuroinflammatory Response Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity Localization Of Cell Acetylglucosaminyltransferase Activity Regulation Of Meiotic Nuclear Division Protein O-linked Glycosylation Via N-acetyl-galactosamine Basement Membrane Organization Dentate Gyrus Development Manganese Ion Binding Regulation Of Meiotic Cell Cycle
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