POMGNT1 and CXorf66

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POMGNT1	CXorf66
Description		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	chromosome X open reading frame 66
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Membrane
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	Protein Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Brain Development Sensory Perception Of Sound Gene Expression Protein O-linked Glycosylation Via N-acetyl-galactosamine Dentate Gyrus Development Protein O-linked Glycosylation Via Mannose Protein Modification Process Myelination Localization Of Cell Basement Membrane Organization Reactive Gliosis
Pathways		Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 core M2 glycosylations DAG1 core M1 glycosylations Matriglycan biosynthesis on DAG1
Drugs
Diseases		Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Body mass index ( 26426971)
Interacting Genes		14 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 GOLPH3 GOLPH3L LNX1 MBD1 RXYLT1 SOX6 TMEM237 ZBTB18	12 interacting genes: AQP6 ASPH EMD ERGIC3 LAT POMGNT1 RPRM RTP2 STX10 TMEM31 TMX2 YIPF6
Entrez ID		55624	347487
HPRD ID		09493	18139
Ensembl ID		ENSG00000085998	ENSG00000203933
Uniprot IDs		A0A8I5KNB7 B7Z7F2 B7Z7Q4 Q8WZA1	Q5JRM2
PDB IDs		5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Cisterna Golgi Membrane Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Granulocyte Chemotaxis Phosphatidylinositol-4-phosphate Binding Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Neutrophil Migration Regulation Of Fatty Acid Biosynthetic Process MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Granulocyte Chemotaxis Ribitol Beta-1,4-xylosyltransferase Activity Positive Regulation Of Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macrophage Migration Inhibitory Factor Binding Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Interleukin-8 Receptor Binding Retrograde Transporter Complex, Golgi To ER Golgi Vesicle Transport Golgi Cisterna Membrane Asymmetric Golgi Ribbon Formation Positive Regulation Of Establishment Of Protein Localization	Membrane Cortical Endoplasmic Reticulum Positive Regulation Of Intracellular Protein Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Transport COPII-coated ER To Golgi Transport Vesicle PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Intracellular Transport Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport TMEM240-body Golgi Membrane Golgi Apparatus Golgi Vesicle Transport TCR Signalosome Retrograde Transporter Complex, Golgi To ER Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Endoplasmic Reticulum Detection Of Chemical Stimulus Regulation Of Protein Localization Cellular Localization Transporter Complex Olfactory Receptor Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Localization Regulation Of Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Localization Of Cell Positive Regulation Of Store-operated Calcium Channel Activity Reactive Gliosis
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