POMGNT1 and CISD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POMGNT1	CISD2
Description		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	CDGSH iron sulfur domain 2
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Brain Development Sensory Perception Of Sound Gene Expression Protein O-linked Glycosylation Via N-acetyl-galactosamine Dentate Gyrus Development Protein O-linked Glycosylation Via Mannose Protein Modification Process Myelination Localization Of Cell Basement Membrane Organization Reactive Gliosis	Autophagy Of Mitochondrion Autophagy Regulation Of Autophagy
Pathways		Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 core M2 glycosylations DAG1 core M1 glycosylations Matriglycan biosynthesis on DAG1
Drugs
Diseases		Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Body mass index ( 26426971)	Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		14 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 GOLPH3 GOLPH3L LNX1 MBD1 RXYLT1 SOX6 TMEM237 ZBTB18	58 interacting genes: AIG1 APOL2 APP AQP10 ARLN BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		55624	493856
HPRD ID		09493	17413
Ensembl ID		ENSG00000085998	ENSG00000145354
Uniprot IDs		A0A8I5KNB7 B7Z7F2 B7Z7Q4 Q8WZA1	Q8N5K1
PDB IDs		5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC	3FNV 4OO7 4OOA 7P0P
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Cisterna Golgi Membrane Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Granulocyte Chemotaxis Phosphatidylinositol-4-phosphate Binding Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Neutrophil Migration Regulation Of Fatty Acid Biosynthetic Process MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Granulocyte Chemotaxis Ribitol Beta-1,4-xylosyltransferase Activity Positive Regulation Of Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macrophage Migration Inhibitory Factor Binding Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Interleukin-8 Receptor Binding Retrograde Transporter Complex, Golgi To ER Golgi Vesicle Transport Golgi Cisterna Membrane Asymmetric Golgi Ribbon Formation Positive Regulation Of Establishment Of Protein Localization	Membrane Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Lipid Metabolic Process
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