PPP1R9A and ACTG1

Number of citations of the paper that reports this interaction (PubMedID 9362513)
58

Data Source:
HPRD (in vitro, in vivo)

		PPP1R9A	ACTG1
Description		protein phosphatase 1 regulatory subunit 9A	actin gamma 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuron Projection Dendritic Spine Synapse Plasma Membrane Bounded Cell Projection	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Myofibril Axon Filamentous Actin NuA4 Histone Acetyltransferase Complex Apical Junction Complex Calyx Of Held Apical Part Of Cell Synapse Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Basal Body Patch
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Hydrolase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Actin Filament Organization Nervous System Development Calcium-mediated Signaling Cell Differentiation Neuron Projection Development Modulation Of Chemical Synaptic Transmission	Angiogenesis Morphogenesis Of A Polarized Epithelium Axonogenesis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Sarcomere Organization Cell Motility Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Platelet Aggregation Cellular Response To Type II Interferon Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Protein Localization To Bicellular Tight Junction
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Copper Artenimol
Diseases
GWAS		Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Waist circumference ( 28552196)	Alanine aminotransferase levels ( 33339817 33547301) Gamma glutamyl transferase levels ( 33339817) Hand grip strength ( 29313844) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ACTG1 MECOM PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2	72 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CEBPA CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FNDC3B FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC00941 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WEE2-AS1 WIPF1
Entrez ID		55607	71
HPRD ID		16000	00017
Ensembl ID		ENSG00000158528	ENSG00000184009
Uniprot IDs		A4D1I0 B7ZLX4 Q9ULJ8	P63261
PDB IDs		1WF8	5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2 7NVM 8DNF
Enriched GO Terms of Interacting Partners?		PTW/PP1 Phosphatase Complex Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Energy Derivation By Oxidation Of Organic Compounds Circadian Regulation Of Gene Expression Phosphatase Activity Glutamatergic Synapse Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Phosphatase Type 1 Complex Generation Of Precursor Metabolites And Energy Regulation Of Circadian Rhythm Dephosphorylation Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Translation In Response To Stress Phosphoprotein Phosphatase Activity Dendritic Spine Protein Serine/threonine/tyrosine Kinase Activity Synapse Chromosome, Telomeric Region Postsynapse Intracellular Signal Transduction Protein Phosphatase Inhibitor Activity Rhythmic Process Basal Body Patch Nucleoplasm Myosin-light-chain-phosphatase Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane TORC1 Signaling Cellular Response To Type II Interferon Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity TOR Signaling Negative Regulation Of TOR Signaling Intracellular Signaling Cassette Schaffer Collateral - CA1 Synapse Response To Type II Interferon Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	Actin Binding Actin Filament Organization Actin Filament-based Process Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Actin Filament Binding Cytoskeleton Actin Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Actin Filament Severing Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Lamellipodium Cell Projection Organization Cytoplasm Modification Of Postsynaptic Structure Positive Regulation Of Cellular Component Organization Modification Of Synaptic Structure Regulation Of Protein-containing Complex Disassembly Glutamatergic Synapse Positive Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cytoskeleton Organization Actin Filament Fragmentation Protein Depolymerization Organelle Organization Plasma Membrane Bounded Cell Projection Organization Presynapse Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis
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