PPP1R9A and RPS6KB1

Number of citations: 34 (PubMedID 12052877)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		PPP1R9A	RPS6KB1
Name		protein phosphatase 1 regulatory subunit 9A	ribosomal protein S6 kinase B1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuron Projection Dendritic Spine Synapse Plasma Membrane Bounded Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Neuron Projection Synapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Actin Filament Organization Nervous System Development Calcium-mediated Signaling Cell Differentiation Neuron Projection Development Modulation Of Chemical Synaptic Transmission	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Cytoplasmic Translation Regulation Of Translation Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Signal Transduction Germ Cell Development Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Peptidyl-serine Phosphorylation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Cellular Response To Insulin Stimulus TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Type II Interferon Cellular Response To Growth Factor Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	mTORC1-mediated signalling
GWAS		Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699 ) Waist circumference ( 28552196 )	A body shape index ( 34021172 ) C-reactive protein levels ( 30388399 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 ) Obesity-related traits ( 23251661 ) Triglycerides ( 30275531 )
Interacting Genes		11 interacting genes: ACTG1 MECOM PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2	61 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 UBC URI1 USP11 XPO1
Entrez ID		55607	6198
HPRD ID		16000	10202
Ensembl ID		ENSG00000158528	ENSG00000108443
Uniprot IDs		A4D1I0 B7ZLX4 Q9ULJ8	P23443
PDB IDs		1WF8	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK 7N91 7N93
GO Terms Enriched among Interactors		PTW/PP1 Phosphatase Complex Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Energy Derivation By Oxidation Of Organic Compounds Circadian Regulation Of Gene Expression Phosphatase Activity Glutamatergic Synapse Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Phosphatase Type 1 Complex Generation Of Precursor Metabolites And Energy Regulation Of Circadian Rhythm Dephosphorylation Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Translation In Response To Stress Phosphoprotein Phosphatase Activity Dendritic Spine Protein Serine/threonine/tyrosine Kinase Activity Synapse Chromosome, Telomeric Region Postsynapse Intracellular Signal Transduction Protein Phosphatase Inhibitor Activity Rhythmic Process Basal Body Patch Nucleoplasm Myosin-light-chain-phosphatase Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane TORC1 Signaling Cellular Response To Type II Interferon Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity TOR Signaling Negative Regulation Of TOR Signaling Intracellular Signaling Cassette Schaffer Collateral - CA1 Synapse Response To Type II Interferon Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	Intracellular Signal Transduction TOR Signaling Regulation Of Protein Metabolic Process Regulation Of Autophagy Cytosol Kinase Activity TORC1 Signaling Protein Kinase Activity Regulation Of TORC1 Signaling Positive Regulation Of Catabolic Process Protein Phosphorylation Regulation Of TOR Signaling Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Signal Transduction Cellular Response To Nutrient Levels Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of TOR Signaling Peptidyl-threonine Phosphorylation Cytoplasm Transferase Activity Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Autophagy Regulation Of Translational Initiation Cellular Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Modification Process Protein Serine Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Cell Projection Organization Positive Regulation Of Autophagy Response To Stress Negative Regulation Of TOR Signaling