PRIM2 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (pull down, biochemical, biochemical, biochemical)

		PRIM2	POLA2
Description		DNA primase subunit 2	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding	DNA Binding Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		7 interacting genes: KDM1A OGT POLA1 POLA2 PRIM1 RECK SUV39H1	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		5558	23649
HPRD ID		08900	10160
Ensembl ID		ENSG00000146143	ENSG00000014138
Uniprot IDs		P49643	A0A9L9PY44 H0YDR7 Q14181
PDB IDs		3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V	2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication Initiation Regulation Of Transcription By Glucose Macromolecule Biosynthetic Process Nucleoplasm DNA Replication Chromatin Binding Embryonic Forelimb Morphogenesis Developmental Maturation Forelimb Morphogenesis Macromolecule Metabolic Process Positive Regulation Of Stem Cell Proliferation RNA Metabolic Process Ligamentous Ossification Ribonucleotide Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromatin DNA Binding Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Nucleotidyltransferase Activity Limb Morphogenesis Regulation Of Multicellular Organismal Process Osteoblast Fate Commitment Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair ENoSc Complex Regulation Of Establishment Of Blood-brain Barrier Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ossification Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Leading Strand Elongation Histone H3K9 Trimethyltransferase Activity Circadian Rhythm Protein Demethylase Activity RDNA Heterochromatin Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cold-induced Thermogenesis Regulation Of Transcription From RNA Polymerase II Promoter By Glucose MRF Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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