PRIM2 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRIM2	RECK
Description		DNA primase subunit 2	reversion inducing cysteine rich protein with kazal motifs
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		7 interacting genes: KDM1A OGT POLA1 POLA2 PRIM1 RECK SUV39H1	43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		5558	8434
HPRD ID		08900	05567
Ensembl ID		ENSG00000146143	ENSG00000122707
Uniprot IDs		P49643	A8K9D8 O95980 Q6P9E2
PDB IDs		3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V	8TZP
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication Initiation Regulation Of Transcription By Glucose Macromolecule Biosynthetic Process Nucleoplasm DNA Replication Chromatin Binding Embryonic Forelimb Morphogenesis Developmental Maturation Forelimb Morphogenesis Macromolecule Metabolic Process Positive Regulation Of Stem Cell Proliferation RNA Metabolic Process Ligamentous Ossification Ribonucleotide Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromatin DNA Binding Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Nucleotidyltransferase Activity Limb Morphogenesis Regulation Of Multicellular Organismal Process Osteoblast Fate Commitment Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair ENoSc Complex Regulation Of Establishment Of Blood-brain Barrier Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ossification Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Leading Strand Elongation Histone H3K9 Trimethyltransferase Activity Circadian Rhythm Protein Demethylase Activity RDNA Heterochromatin Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cold-induced Thermogenesis Regulation Of Transcription From RNA Polymerase II Promoter By Glucose MRF Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Keratin Filament Intermediate Filament
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