PRELP and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 11847210)
0

Data Source:
HPRD (in vitro)

		PRELP	HSPG2
Description		proline and arginine rich end leucine rich repeat protein	heparan sulfate proteoglycan 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome Extracellular Vesicle	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding
	Biological Process	Skeletal System Development Cellular Senescence	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297)	Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		6 interacting genes: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1	33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		5549	3339
HPRD ID		03556	00804
Ensembl ID		ENSG00000188783	ENSG00000142798
Uniprot IDs		P51888	P98160
PDB IDs			3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Proteoglycan Binding Basement Membrane Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Positive Regulation Of Cell-substrate Adhesion Extracellular Region Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Extracellular Matrix Binding Extracellular Matrix Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Structure Organization Anatomical Structure Formation Involved In Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Collagen Binding Cellular Response To Vitamin E Collagen Trimer System Development Cartilage Development Collagen Type I Trimer Protease Binding Cellular Response To Fluoride Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Collagen V Binding Skeletal System Morphogenesis Ossification Collagen Type II Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate CAF-1 Complex Animal Organ Development Calcium Ion Binding Response To Fluoride Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Extracellular Space Calcium-independent Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Collagen Type XI Trimer Anterior Head Development Intramembranous Ossification Visual Perception Skeletal System Development	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development
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