PRELP and FBLN2

Number of citations of the paper that reports this interaction (PMID 11847210)
16

Data Source:
HPRD (in vitro)

		PRELP	FBLN2
Gene Name		proline/arginine-rich end leucine-rich repeat protein	fibulin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Vesicle Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Aging Pathogenesis Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		7 interactors: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1 NID2	22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408
Entrez ID		5549	2199
HPRD ID		03556	00630
Ensembl ID		ENSG00000188783	ENSG00000163520
Uniprot IDs		P51888	F5H1F3 P98095 Q86V58 Q9Y3V7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Endochondral Bone Morphogenesis Bone Morphogenesis Embryonic Skeletal System Development Cell-matrix Adhesion Basement Membrane Organization Regulation Of Cell-substrate Adhesion Cartilage Development Cell-substrate Adhesion Bone Development Connective Tissue Development Skeletal System Morphogenesis Ossification Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Collagen Fibril Organization Collagen Catabolic Process Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Multicellular Organismal Metabolic Process Cellular Response To Fluoride Blood Vessel Development Vasculature Development Proteoglycan Metabolic Process Skeletal System Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Tooth Eruption Response To Fluoride Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Tissue Development Sensory Perception Of Sound Positive Regulation Of Cell Morphogenesis Involved In Differentiation Visual Perception Calcium-independent Cell-matrix Adhesion Chordate Embryonic Development Sensory Perception Of Light Stimulus Embryo Development Ending In Birth Or Egg Hatching Sensory Perception Of Mechanical Stimulus Platelet Activation Cellular Response To Vitamin E Leukocyte Migration Organ Morphogenesis	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Intersection) ?