STRADB and SF3B1

		STRADB	SF3B1
Description		STE20 related adaptor beta	splicing factor 3b subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Aggresome Serine/threonine Protein Kinase Complex	Chromatin Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nucleolus Nuclear Speck Nuclear Lumen U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome B-WICH Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Cell Morphogenesis Protein Phosphorylation Protein Export From Nucleus JNK Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Chromatin Remodeling MRNA Processing RNA Splicing Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III U2-type Prespliceosome Assembly
Pathways		Energy dependent regulation of mTOR by LKB1-AMPK	B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs			H3B-8800
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: CAB39 GRB2 MAP3K7 NEB STK11 TRAF6 UBC XIAP	102 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG H3C1 IL7R MECOM MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NRIP1 NUDT21 PPP1R8 RBM17 RSPH1 SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 SUMO2 TCERG1 TOP1 USP7 WBP4
Entrez ID		55437	23451
HPRD ID		09546	09281
Ensembl ID		ENSG00000082146	ENSG00000115524
Uniprot IDs		Q9C0K7	B4DGZ4 O75533
PDB IDs			2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6AHD 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7SN6 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Binding Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical NF-kappaB Signal Transduction Interleukin-17A-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Anoikis Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway T Cell Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Modification Process DNA Damage Response Regulation Of Type I Interferon Production Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Serine/threonine Protein Kinase Complex Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway P38MAPK Cascade Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Cellular Response To Stress Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Activation Of Innate Immune Response Activation Of Protein Kinase Activity Regulation Of T Cell Cytokine Production Protein Kinase Activator Activity Toll-like Receptor 4 Signaling Pathway	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Endothelial Cell Migration
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