LGR4 and RSPO2

Number of citations of the paper that reports this interaction (PMID 24050775)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		LGR4	RSPO2
Gene Name		leucine-rich repeat containing G protein-coupled receptor 4	R-spondin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity Protein Binding	G-protein Coupled Receptor Binding Receptor Binding Heparin Binding
	Biological Process	Osteoblast Differentiation G-protein Coupled Receptor Signaling Pathway Spermatogenesis Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829)
Protein-Protein Interactions		3 interactors: RSPO2 RSPO3 RSPO4	8 interactors: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 PLEKHF2 SUV39H1
Entrez ID		55366	340419
HPRD ID		05978	17536
Ensembl ID		ENSG00000205213	ENSG00000147655
Uniprot IDs		Q59ER8 Q9BXB1	B3KVP3 Q6UXX9
PDB IDs		4KT1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Lung Growth Trachea Cartilage Morphogenesis Trachea Cartilage Development Branching Involved In Labyrinthine Layer Morphogenesis Morphogenesis Of An Epithelium Regulation Of Signal Transduction Trachea Morphogenesis Cartilage Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Labyrinthine Layer Morphogenesis Trachea Development Embryonic Placenta Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Bone Mineralization Embryonic Forelimb Morphogenesis Epithelium Development Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryo Development Hindlimb Morphogenesis Labyrinthine Layer Development Lung Morphogenesis Biomineral Tissue Development Signal Transduction Canonical Wnt Signaling Pathway Organ Growth Signaling Cell Communication Embryonic Placenta Development Tissue Development Osteoblast Differentiation Embryonic Limb Morphogenesis Cellular Response To Stimulus Limb Morphogenesis Cartilage Development Placenta Development Limb Development Branching Morphogenesis Of An Epithelial Tube Anatomical Structure Morphogenesis	Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Peptidyl-lysine Modification Rhythmic Process Kidney Development Histone H3-K9 Dimethylation Renal System Development Recognition Of Apoptotic Cell Metanephric Nephron Tubule Morphogenesis Urogenital System Development Histone Modification Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Chromatin Silencing At RDNA Phagocytosis, Recognition Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Negative Regulation Of Circadian Rhythm Regulation Of Branching Involved In Ureteric Bud Morphogenesis Chromatin Modification Histone H3-K9 Methylation Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Peptidyl-lysine Trimethylation Protein Hydroxylation Male Genitalia Development Metanephric Epithelium Development Macrophage Activation Tube Development Chromatin Organization Apoptotic Cell Clearance Metanephros Morphogenesis Chromatin Silencing Histone Demethylation Histone H3-K9 Modification Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Protein Demethylation Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Erythrocyte Development Bone Mineralization Peptidyl-amino Acid Modification Sprouting Angiogenesis
Tagcloud ?		293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lh named naturally newborn norrin rodent rspo2 splice spondin spondins steroidogenic superovulated testicular tune wnt	293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lgr4 lh named naturally newborn norrin rodent splice spondin spondins steroidogenic superovulated testicular tune wnt
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lgr4 lh named naturally newborn norrin rodent rspo2 splice spondin spondins steroidogenic superovulated testicular tune wnt