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LGR4 and RSPO3
Number of citations of the paper that reports this interaction (PMID
24050775
)
2
Data Source:
BioGRID
(fluorescent resonance energy transfer)
LGR4
RSPO3
Gene Name
leucine-rich repeat containing G protein-coupled receptor 4
R-spondin 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Extracellular Region
Extracellular Space
Molecular Function
Transmembrane Signaling Receptor Activity
G-protein Coupled Receptor Activity
Protein Binding
G-protein Coupled Receptor Binding
Receptor Binding
Frizzled Binding
Heparin Binding
Biological Process
Osteoblast Differentiation
G-protein Coupled Receptor Signaling Pathway
Spermatogenesis
Bone Mineralization
Male Genitalia Development
Circadian Regulation Of Gene Expression
Negative Regulation Of Toll-like Receptor Signaling Pathway
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Bone Remodeling
Epithelial Cell Proliferation
Negative Regulation Of Cytokine Secretion
Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development
Cell Differentiation Involved In Metanephros Development
Metanephric Glomerulus Development
Metanephric Nephron Tubule Morphogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
regulation of FZD by ubiquitination
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
regulation of FZD by ubiquitination
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Bone mineral density (
21533022
22504420
)
Intracranial volume (
22504418
)
Iron status biomarkers (
19084217
)
Metabolite levels (
21909109
)
Renal function-related traits (BUN) (
22797727
)
Waist-hip ratio (
23563607
20935629
)
Protein-Protein Interactions
3 interactors:
RSPO2
RSPO3
RSPO4
1 interactors:
LGR4
Entrez ID
55366
84870
HPRD ID
05978
18181
Ensembl ID
ENSG00000205213
Uniprot IDs
Q59ER8
Q9BXB1
Q9BXY4
PDB IDs
4KT1
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Signal Transduction
Morphogenesis Of A Branching Epithelium
Morphogenesis Of A Branching Structure
Lung Growth
Trachea Cartilage Morphogenesis
Trachea Cartilage Development
Branching Involved In Labyrinthine Layer Morphogenesis
Morphogenesis Of An Epithelium
Regulation Of Signal Transduction
Trachea Morphogenesis
Cartilage Morphogenesis
Embryonic Morphogenesis
Tissue Morphogenesis
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Labyrinthine Layer Morphogenesis
Trachea Development
Embryonic Placenta Morphogenesis
Epithelial Tube Branching Involved In Lung Morphogenesis
Bone Mineralization
Embryonic Forelimb Morphogenesis
Epithelium Development
Embryonic Hindlimb Morphogenesis
Forelimb Morphogenesis
Embryo Development
Hindlimb Morphogenesis
Labyrinthine Layer Development
Lung Morphogenesis
Biomineral Tissue Development
Signal Transduction
Canonical Wnt Signaling Pathway
Organ Growth
Signaling
Cell Communication
Embryonic Placenta Development
Tissue Development
Osteoblast Differentiation
Embryonic Limb Morphogenesis
Cellular Response To Stimulus
Limb Morphogenesis
Cartilage Development
Placenta Development
Limb Development
Branching Morphogenesis Of An Epithelial Tube
Anatomical Structure Morphogenesis
Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development
Metanephric Nephron Tubule Morphogenesis
Cell Differentiation Involved In Metanephros Development
Metanephric Tubule Morphogenesis
Metanephric Glomerulus Development
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Metanephric Nephron Tubule Development
Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Metanephric Nephron Morphogenesis
Negative Regulation Of Toll-like Receptor Signaling Pathway
Male Genitalia Development
Metanephric Epithelium Development
Metanephros Morphogenesis
Negative Regulation Of Cytokine Secretion
Positive Regulation Of Kidney Development
Cell Differentiation Involved In Kidney Development
Metanephric Nephron Development
Regulation Of Toll-like Receptor Signaling Pathway
Bone Mineralization
Genitalia Development
Bone Remodeling
Glomerulus Development
Regulation Of Morphogenesis Of A Branching Structure
Biomineral Tissue Development
Circadian Regulation Of Gene Expression
Nephron Morphogenesis
Renal Tubule Morphogenesis
Epithelial Cell Proliferation
Canonical Wnt Signaling Pathway
Renal Tubule Development
Negative Regulation Of Protein Secretion
Kidney Morphogenesis
Metanephros Development
Tissue Remodeling
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Cytokine Secretion
Osteoblast Differentiation
Nephron Development
Positive Regulation Of Wnt Signaling Pathway
Kidney Epithelium Development
Negative Regulation Of Secretion By Cell
Circadian Rhythm
Negative Regulation Of Secretion
Regulation Of Organ Morphogenesis
Negative Regulation Of Protein Transport
Male Sex Differentiation
Negative Regulation Of Cytokine Production
Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway
Ossification
Tagcloud
?
293t
aquaporin
bring
cdnas
conditioned
conservation
dependently
ectodomain
ed
endogenously
gonadal
gonads
intraperitoneal
leucine
lh
named
naturally
newborn
norrin
rodent
rspo2
splice
spondin
spondins
steroidogenic
superovulated
testicular
tune
wnt
Tagcloud (Difference)
?
293t
aquaporin
bring
cdnas
conditioned
conservation
dependently
ectodomain
ed
endogenously
gonadal
gonads
intraperitoneal
leucine
lh
named
naturally
newborn
norrin
rodent
rspo2
splice
spondin
spondins
steroidogenic
superovulated
testicular
tune
wnt
Tagcloud (Intersection)
?