| Name |
leucine rich repeat containing G protein-coupled receptor 4 |
R-spondin 3 |
| Structure |
|
No pdb structure
|
| GO Annotations |
Cellular Component |
|
|
| Molecular Function |
|
|
| Biological Process |
|
|
| Pathways |
|
|
| GWAS |
- Blond vs. brown/black hair color ( 30531825
)
- Bone mineral density ( 23644456
)
- Bone mineral density (paediatric, skull) ( 24945404
)
- Brain morphology (MOSTest) ( 32665545
)
- Dental caries (decayed, missing and filled teeth) ( 31533690
)
- Heel bone mineral density ( 30598549
)
- Male-pattern baldness ( 28196072
)
- Menarche (age at onset) ( 25231870
)
- Spontaneous preterm birth with premature rupture of membranes ( 31194736
)
- Survival in pancreatic cancer ( 28470677
)
- Urate levels in obese individuals ( 25811787
)
|
- A body shape index ( 34021172
)
- Alanine aminotransferase levels ( 34315874
)
- Apolipoprotein A1 levels ( 32203549
)
- Apolipoprotein B levels ( 32203549
)
- Appendicular lean mass ( 33097823
)
- Aspartate aminotransferase levels ( 33547301
34315874
)
- Blood pressure ( 23972371
)
- Blood protein levels ( 30072576
)
- Blood urea nitrogen levels ( 29403010
31152163
)
- Bone mineral density ( 21533022
)
- Bone mineral density (paediatric, skull) ( 24945404
)
- Bone mineral density (paediatric, total body less head) ( 24945404
)
- Bone mineral density (paediatric, upper limb) ( 24945404
)
- Bone mineral density (spine) ( 26733130
)
- Bone properties (heel) ( 24430505
)
- Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463
)
- Bone ultrasound measurement (velocity of sound) ( 28472463
)
- C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809
)
- Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216
)
- Cortical surface area ( 32963231
)
- Cortical volume ( 32963231
)
- Crohn's disease ( 28067908
)
- Diastolic blood pressure ( 27618452
27841878
28739976
29403010
30487518
)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858
)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962
)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098
)
- Fasting insulin ( 34059833
)
- Femoral neck bone mineral density ( 22504420
29499414
)
- Food addiction ( 27106561
)
- Fractures ( 30158200
30598549
)
- HDL cholesterol ( 24097068
30275531
)
- HDL cholesterol levels ( 28334899
30698716
32203549
)
- HDL cholesterol levels in current drinkers ( 30698716
)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716
)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716
)
- HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535
)
- HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535
)
- Heel bone mineral density ( 28869591
30048462
30598549
)
- Hematocrit ( 32888494
)
- Hemoglobin ( 32888494
)
- Hemoglobin concentration ( 27863252
)
- Hemoglobin levels ( 32327693
)
- High density lipoprotein cholesterol levels ( 33339817
)
- Hip circumference ( 31453325
)
- Hip circumference adjusted for BMI ( 25673412
34021172
)
- Hip circumference variance ( 31453325
)
- Hip index ( 34021172
)
- Intracranial volume ( 22504418
)
- Iron status biomarkers ( 19084217
)
- LDL cholesterol levels ( 32203549
)
- LDL cholesterol levels in HIV infection ( 33109212
)
- Liver enzyme levels (gamma-glutamyl transferase) ( 33972514
)
- Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025
)
- Liver volume ( 34128465
)
- Low density lipoprotein cholesterol levels ( 32154731
)
- Lung function (FVC) ( 30061609
)
- Lymphocyte count ( 32888494
)
- Lymphocyte percentage of white cells ( 32888494
)
- Male-pattern baldness ( 27182965
)
- Mean arterial pressure ( 29403010
30487518
)
- Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962
)
- Medication use (HMG CoA reductase inhibitors) ( 31015401
)
- Menarche (age at onset) ( 27182965
)
- Metabolic syndrome ( 31589552
)
- Metabolite levels ( 21909109
)
- Monobrow ( 27182965
)
- Neutrophil percentage of white cells ( 32888494
)
- Occipital lobe volume ( 31396565
)
- Optic disc size ( 31809533
)
- Pancreas volume ( 34128465
)
- Pulse pressure ( 27841878
)
- QT interval ( 29213071
)
- Red blood cell count ( 27863252
32888494
)
- Renal function-related traits (BUN) ( 22797727
)
- Serum urea levels ( 30808845
)
- Subcortical brain region volumes ( 25607358
)
- Systolic blood pressure ( 27618452
27841878
28739976
30487518
)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858
)
- Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962
)
- Triglyceride levels ( 28334899
32154731
32203549
)
- Triglyceride levels in current drinkers ( 30698716
)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716
)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716
)
- Triglycerides ( 24097068
25961943
)
- Waist circumference ( 25673412
)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625
)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500
)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625
)
- Waist circumference adjusted for BMI in active individuals ( 28448500
)
- Waist circumference adjusted for BMI in non-smokers ( 28443625
)
- Waist circumference adjusted for body mass index ( 25673412
28448500
28552196
34021172
)
- Waist-hip index ( 34021172
)
- Waist-hip ratio ( 20935629
23563607
25673412
28552196
)
- Waist-to-hip ratio adjusted for BMI ( 26426971
28552196
34021172
)
- Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226
)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625
)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971
)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500
)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625
)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500
)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625
)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971
)
- Waist-to-hip ratio adjusted for body mass index ( 25673412
28270201
28448500
)
|
| Interacting Genes |
4 interacting genes:
MARCHF2
RSPO1
RSPO3
RSPO4
|
4 interacting genes:
HRAS
LGR4
MTDH
ZNRF3
|
| Entrez ID |
55366 |
84870 |
| HPRD ID |
05978
|
18181
|
| Ensembl ID |
ENSG00000205213
|
ENSG00000146374
|
| Uniprot IDs |
Q59ER8
Q9BXB1
|
Q9BXY4
|
| PDB IDs |
4KT1
4QXE
4QXF
8WVU
8WVV
8WVW
8WVX
8WVY
8XFP
8XFS
8XFT
8XT9
8XUM
8Y69
|
Not available
|
| GO Terms Enriched among Interactors |
|
|