LGR4

Gene Name		leucine-rich repeat containing G protein-coupled receptor 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity Protein Binding
	Biological Process	Osteoblast Differentiation G-protein Coupled Receptor Signaling Pathway Spermatogenesis Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: RSPO2 RSPO3 RSPO4
Entrez ID		55366
HPRD ID		05978
Ensembl ID		ENSG00000205213
Uniprot IDs		Q59ER8 Q9BXB1
PDB IDs		4KT1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Lung Growth Trachea Cartilage Morphogenesis Trachea Cartilage Development Branching Involved In Labyrinthine Layer Morphogenesis Morphogenesis Of An Epithelium Regulation Of Signal Transduction Trachea Morphogenesis Cartilage Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Labyrinthine Layer Morphogenesis Trachea Development Embryonic Placenta Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Bone Mineralization Embryonic Forelimb Morphogenesis Epithelium Development Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryo Development Hindlimb Morphogenesis Labyrinthine Layer Development Lung Morphogenesis Biomineral Tissue Development Signal Transduction Canonical Wnt Signaling Pathway Organ Growth Signaling Cell Communication Embryonic Placenta Development Tissue Development Osteoblast Differentiation Embryonic Limb Morphogenesis Cellular Response To Stimulus Limb Morphogenesis Cartilage Development Placenta Development Limb Development Branching Morphogenesis Of An Epithelial Tube Anatomical Structure Morphogenesis
Tagcloud ?		293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lh named naturally newborn norrin rodent rspo2 splice spondin spondins steroidogenic superovulated testicular tune wnt